Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
Asian J Psychiatr. 2021 Mar;57:102593. doi: 10.1016/j.ajp.2021.102593. Epub 2021 Feb 5.
In the light of shared genetic underpinnings of schizophrenia and bipolar disorder, their comparative profile of social cognition (SC) performance - an intermittent phenotype and determinant of functional outcome - is poorly understood. Using data from 160 individuals, we identify unique patterns of composite and domain-specific SC-abilities between these groups after controlling for their neurocognition. Individuals with schizophrenia and not bipolar disorder demonstrated deficits in composite SC-measures, which were not associated with their functional status. While patients with bipolar disorder had significantly lower scores on emotion recognition, they outperformed the healthy and schizophrenia groups on the second-order theory of mind.
鉴于精神分裂症和双相情感障碍在遗传基础上存在共同之处，它们在社会认知（SC）表现方面的比较情况（间歇性表型和功能结果的决定因素）尚未得到充分理解。本研究使用 160 名个体的数据，在控制神经认知的情况下，确定了这两个群体之间复合和特定领域的 SC 能力的独特模式。与功能状态无关，患有精神分裂症而非双相情感障碍的个体在复合 SC 测量方面存在缺陷。尽管患有双相情感障碍的患者在情绪识别方面的得分明显较低，但他们在二阶心理理论方面的表现优于健康对照组和精神分裂症组。
