EEG and evoked potential approaches to the study of neuropeptides.

EEG and event related potential (ERP) phenomena were considered here from the standpoint of possible applications to investigations of the central effects of neuropeptides in man. These electrophysiological phenomena were viewed from the standpoint that they provide an accessible intermediate level of observation between behavior and detailed neuronal events. Several general methodological issues were discussed. An attempt was made to describe the EEG and ERP phenomena that may be pertinent to future neuropeptide studies and to consider their functional significance. Available data concerning electrophysiological effects of neuropeptides were also discussed. Suggestions for future research were made, which emphasized comprehensive recording of EEG and ERP phenomena to permit examination of the patterning of electrocerebral events.