Key Laboratory of Freshwater Aquatic Genetic Resources Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, China.
National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China.
Fish Shellfish Immunol. 2021 Apr;111:201-207. doi: 10.1016/j.fsi.2021.02.003. Epub 2021 Feb 11.
Septicemia of grass carp is a systemic inflammatory reaction caused by bacterial infection. More and more evidences show that long non-coding RNAs (lncRNAs) can participate in the regulation of inflammatory response. In the present study, lncRNA-WAS and lncRNA-C8807 were confirmed to be involved in the inflammatory response following infection with Aeromonas hydrophila. LncRNA-WAS and lncRNA-C8807 could interact with miR-142a-3p. LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to effect pro-inflammatory genes and NF-κB pathway. Our results provide a theoretical basis for studying the molecular mechanism underlying the regulation of inflammation by lncRNA in grass carp.
草鱼败血症是由细菌感染引起的全身性炎症反应。越来越多的证据表明，长链非编码 RNA（lncRNA）可以参与炎症反应的调节。在本研究中，lncRNA-WAS 和 lncRNA-C8807 被证实参与了嗜水气单胞菌感染后的炎症反应。lncRNA-WAS 和 lncRNA-C8807 可以与 miR-142a-3p 相互作用。lncRNA-WAS 和 lncRNA-C8807 通过与 miR-142a-3p 相互作用来影响促炎基因和 NF-κB 通路。我们的研究结果为研究 lncRNA 在草鱼中调节炎症的分子机制提供了理论依据。
