Universidad de la Sabana, Chía, Colombia.
Universidad de la Sabana, Chía, Colombia; Clínica Universidad de La Sabana, Chía, Colombia.
Int J Infect Dis. 2021 Apr;105:32-39. doi: 10.1016/j.ijid.2021.02.031. Epub 2021 Feb 11.
Invasive pneumococcal disease (IPD) is the leading cause of infectious death worldwide. This study aimed to describe the epidemiology of IPD and the impact of pneumococcal conjugate vaccine-10 (PCV-10) over a 10-year period in Bogotá, Colombia.
This was a laboratory-based surveillance study of Streptococcus pneumoniae isolated from patients with IPD from 82 hospitals over 10 years in Bogotá, Colombia. Data were compared between two periods: 2007-2011 (before the introduction of PCV-10) and 2012-2017 (after the introduction of PCV-10).
In total, 1670 patients with IPD were included in the study between 2007 and 2017. Between 2007 and 2011, the most common serotypes were 14, 1, 6B, 6A and 3. Between 2012 and 2017, the most common serotypes were 19A, 3, 14 and 1. A decrease in the incidence of IPD, particularly in children aged 0-4 years, was noted after the introduction of PCV-10. Importantly, this reduction in incidence was not observed in patients aged ≥50 years.
The IPD burden in Bogotá remained stable between 2007 and 2017. The incidence of IPD decreased in children but not in older adults. The introduction of PCV-10 led to a change in the most prevalent serotypes to serotypes that are not included in PCV-10.
侵袭性肺炎球菌病（IPD）是全球传染性死亡的主要原因。本研究旨在描述 10 年来哥伦比亚波哥大侵袭性肺炎球菌病的流行病学和肺炎球菌结合疫苗 10 型（PCV-10）的影响。
这是一项基于实验室的对从波哥大 82 家医院的 IPD 患者中分离出的肺炎链球菌的监测研究，时间跨度为 10 年。数据在两个时期进行了比较：2007-2011 年（PCV-10 引入前）和 2012-2017 年（PCV-10 引入后）。
2007 年至 2017 年期间，共有 1670 名 IPD 患者纳入本研究。2007-2011 年期间，最常见的血清型为 14、1、6B、6A 和 3。2012-2017 年期间，最常见的血清型为 19A、3、14 和 1。PCV-10 引入后，IPD 的发病率，特别是 0-4 岁儿童的发病率有所下降。重要的是，在≥50 岁的患者中未观察到发病率的这种下降。
2007 年至 2017 年间，波哥大的 IPD 负担保持稳定。儿童 IPD 的发病率下降，但老年人的发病率没有下降。PCV-10 的引入导致最常见的血清型发生变化，不再包括在 PCV-10 中的血清型。
