Clinical Research Center and Division of Mood Disorders of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Neurosci Bull. 2021 Jun;37(6):863-880. doi: 10.1007/s12264-021-00638-3. Epub 2021 Feb 13.
Major depressive disorder (MDD), also referred to as depression, is one of the most common psychiatric disorders with a high economic burden. The etiology of depression is still not clear, but it is generally believed that MDD is a multifactorial disease caused by the interaction of social, psychological, and biological aspects. Therefore, there is no exact pathological theory that can independently explain its pathogenesis, involving genetics, neurobiology, and neuroimaging. At present, there are many treatment measures for patients with depression, including drug therapy, psychotherapy, and neuromodulation technology. In recent years, great progress has been made in the development of new antidepressants, some of which have been applied in the clinic. This article mainly reviews the research progress, pathogenesis, and treatment of MDD.
重度抑郁症（MDD），也称为抑郁症，是最常见的精神疾病之一，具有很高的经济负担。抑郁症的病因尚不清楚，但一般认为 MDD 是一种由社会、心理和生物方面相互作用引起的多因素疾病。因此，没有确切的病理理论可以独立解释其发病机制，涉及遗传学、神经生物学和神经影像学。目前，抑郁症患者有许多治疗措施，包括药物治疗、心理治疗和神经调节技术。近年来，新型抗抑郁药的开发取得了很大进展，其中一些已应用于临床。本文主要综述了 MDD 的研究进展、发病机制和治疗方法。
