Department of Neurology, Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.
Department of Pathology, Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.
J Int Med Res. 2021 Feb;49(2):300060521992231. doi: 10.1177/0300060521992231.
Paraneoplastic cerebellar degeneration (PCD) is a neurological syndrome that is likely caused by tumor-induced autoimmunity against the cerebellum. Neuroendocrine carcinoma (NEC) is a type of neoplasm with high-grade malignant histology and biological behavior. The prognosis for both PCD and NEC is typically poor. We report a case of PCD secondary to metastatic NEC in the lymph nodes, with an unknown primary origin. The case presented acute cerebellar manifestations with typical neuroimaging findings, but with atypical prognosis after lymph node dissection. Neurological symptoms can provide clues to potential tumors, and early antitumor treatment may have contributed to the positive prognosis of PCD secondary to NEC in the present case.
副肿瘤性小脑变性（PCD）是一种神经系统综合征，可能由肿瘤诱导的针对小脑的自身免疫引起。神经内分泌癌（NEC）是一种具有高级别恶性组织学和生物学行为的肿瘤类型。PCD 和 NEC 的预后通常都很差。我们报告了一例由淋巴结转移的神经内分泌癌引起的 PCD，其原发灶不明。该病例表现为急性小脑症状，具有典型的神经影像学表现，但在进行淋巴结清扫后预后不典型。神经症状可为潜在肿瘤提供线索，本病例中，早期抗肿瘤治疗可能有助于改善 NEC 继发的 PCD 的预后。
