Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark.
Gynecol Oncol. 2021 May;161(2):458-462. doi: 10.1016/j.ygyno.2021.01.042. Epub 2021 Feb 12.
To examine the influence of socioeconomic status (SES) on long-term survival of non-localized ovarian cancer.
All women in Denmark with a first diagnosis of non-localized epithelial ovarian cancer 1982-2007 were identified in the Cancer Registry and/or the Pathology Registry and followed up until December 2017. The survival probability was estimated after respectively 5 and 10 years, using so-called pseudo observations, and analyzed according to education, income, and marital status defined from nationwide registries.
The study cohort included 6486 women, and the estimated 5- and 10-year survival probabilities were 21.4% and 12.7%, respectively. Compared to women with short education, the 5-year survival probability was 7% higher for women with medium (relative survival probability = 1.07, 95% CI: 0.97, 1.19) and long education (relative survival probability = 1.07, 95% CI: 0.93, 1.24). Compared with married women, the 5-year survival probability for divorced women/widower was slightly lower (0.85, 95% CI: 0.69, 1.04) and for unmarried women slightly higher (1.08, 95% CI: 0.94, 1.23). Finally, the probability of being alive 5 years after diagnosis was 1.09 times higher (95% CI: 0.95, 1.24) for medium-income women and 1.23 times higher (95% CI: 1.08, 1.41) for high-income women compared with low-income women. Similar patterns were observed for 10-year survival.
Non-localized ovarian cancer patients have a poor prognosis. Our data suggest that among Danish women with advanced ovarian cancer, higher personal income is associated with slightly higher probability of long-term survival, whereas education and marital status did not affect the probability of long-term survival.
探讨社会经济地位（SES）对非局部卵巢癌长期生存的影响。
在丹麦，通过癌症登记处和/或病理登记处确定了 1982 年至 2007 年首次诊断为非局部上皮性卵巢癌的所有女性，并随访至 2017 年 12 月。使用所谓的伪观测值估计生存概率，然后根据全国登记册定义的教育、收入和婚姻状况进行分析。
该研究队列包括 6486 名女性，估计 5 年和 10 年的生存率分别为 21.4%和 12.7%。与受教育程度较低的女性相比，受教育程度中等（相对生存率=1.07，95%置信区间：0.97，1.19）和较高（相对生存率=1.07，95%置信区间：0.93，1.24）的女性 5 年生存率提高了 7%。与已婚女性相比，离婚/鳏夫的 5 年生存率略低（0.85，95%置信区间：0.69，1.04），未婚女性的生存率略高（1.08，95%置信区间：0.94，1.23）。最后，与低收入女性相比，中等收入女性 5 年后存活的概率高 1.09 倍（95%置信区间：0.95，1.24），高收入女性高 1.23 倍（95%置信区间：1.08，1.41）。10 年生存率也观察到类似的模式。
非局部卵巢癌患者预后较差。我们的数据表明，在丹麦患有晚期卵巢癌的女性中，个人收入较高与长期生存的概率略有增加相关，而教育和婚姻状况并未影响长期生存的概率。
