Gill D S, Barradas M A, Fonseca V A, Gracey L, Dandona P
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, U.K.
Am J Clin Pathol. 1988 May;89(5):622-6. doi: 10.1093/ajcp/89.5.622.
Since histamine has recently been shown to play an important role in the pathogenesis of atherosclerosis in experimental nonketotic diabetes, and since leukocytes and platelets contain most of the histamine in blood, we have determined the levels of histamine in these cells from patients with peripheral vascular disease (PVD), insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). The leukocyte and platelet histamine concentration in PVDs was significantly greater than that in controls, IDDMs and NIDDMs. Histamine content of leukocytes and platelets from IDDMs and NIDDMs did not differ from that in control subjects. The higher histamine content of leukocytes and platelets in PVD may lead to a greater release of this amine at sites of vascular endothelial damage. Increased histamine release may increase endothelial permeability and contribute to further vascular injury as observed in experimental models of diabetes and hypercholesterolemia.
由于最近研究表明组胺在实验性非酮症糖尿病的动脉粥样硬化发病机制中起重要作用，且白细胞和血小板含有血液中大部分组胺，我们测定了外周血管疾病（PVD）、胰岛素依赖型糖尿病（IDDM）和非胰岛素依赖型糖尿病（NIDDM）患者这些细胞中的组胺水平。PVD患者白细胞和血小板中的组胺浓度显著高于对照组、IDDM患者和NIDDM患者。IDDM患者和NIDDM患者白细胞和血小板中的组胺含量与对照受试者无差异。PVD患者白细胞和血小板中较高的组胺含量可能导致该胺在血管内皮损伤部位大量释放。如在糖尿病和高胆固醇血症实验模型中观察到的，组胺释放增加可能会增加内皮通透性并导致进一步的血管损伤。
