Department of Pediatrics and Adolescent Medicine, Tokyo Medical University.
Department of Pediatrics and Adolescent Medicine, Tokyo Medical University.
J Infect Chemother. 2021 Jun;27(6):840-844. doi: 10.1016/j.jiac.2021.01.019. Epub 2021 Feb 11.
To clarify the pathology of children with acute encephalopathy and other neurological disorders, the involvement of high-mobility group box 1 (HMGB1), which is a representative of danger-associated molecular patterns, and angiogenesis-related growth factors were investigated.
Participants were 12 children with acute encephalopathy (influenza, rotavirus, and others), 7 with bacterial meningitis, and 6 with epilepsy disease (West syndrome). Twenty-four patients with non-central nervous system (CNS) infections as a control group were admitted to our hospital. We examined the levels of HMGB1, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and other cytokines in the serum and cerebrospinal fluid (CSF) of the subjects.
Serum and CSF HMGB1 levels were significantly higher in the encephalopathy and meningitis groups than in the West syndrome and control groups. CSF HMGB1 levels correlated with those of interleukin-6 and -8. CSF HMGB1 and VEGF levels were correlated, and PDGF showed a positive relationship.
HMGB1 and angiogenesis-related growth factors appear to play pivotal roles in the pathophysiology of CNS infections.
为了阐明伴有其他神经障碍的儿童急性脑病的病理学，研究了高迁移率族蛋白 B1（HMGB1）的病理作用，其作为危险相关分子模式的代表之一，以及与血管生成相关的生长因子。
参与者为 12 例患有急性脑病（流感、轮状病毒等）的儿童、7 例患有细菌性脑膜炎的儿童和 6 例患有癫痫疾病（West 综合征）的儿童。24 例非中枢神经系统（CNS）感染的患者作为对照组被收入我院。我们检测了受试者血清和脑脊液（CSF）中 HMGB1、血小板衍生生长因子（PDGF）、血管内皮生长因子（VEGF）和其他细胞因子的水平。
脑病和脑膜炎组的血清和 CSF HMGB1 水平明显高于 West 综合征组和对照组。CSF HMGB1 水平与白细胞介素-6 和 -8 的水平相关。CSF HMGB1 与 VEGF 水平相关，而 PDGF 呈正相关。
HMGB1 和与血管生成相关的生长因子似乎在 CNS 感染的病理生理学中发挥关键作用。
