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经冷冻活检诊断的成人 T 细胞白血病/淋巴瘤患者的急性肺移植物抗宿主病。

Acute Pulmonary Graft-Versus-Host Disease in a Patient with Adult T-cell Leukemia-Lymphoma Diagnosed by a Cryobiopsy.

机构信息

Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Japan.

Department of Hematology/Oncology, Ohara Healthcare Foundation, Kurashiki Central Hospital, Japan.

出版信息

Intern Med. 2021 Jul 15;60(14):2269-2273. doi: 10.2169/internalmedicine.6358-20. Epub 2021 Feb 15.

DOI:10.2169/internalmedicine.6358-20
PMID:33583892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8355406/
Abstract

A 51-year-old woman with adult T-cell leukemia-lymphoma was hospitalized in order to undergo allogeneic hematopoietic stem-cell transplantation. On day 29 after transplantation, she began to experience hypoxia upon exertion. Chest computed tomography revealed centrilobular granular shadows, and pulmonary function tests revealed a remarkable obstructive ventilatory impairment compared to before transplantation. A histopathological analysis following a transbronchial lung cryobiopsy revealed acute graft-versus-host disease (GVHD). We herein report a rare case of histopathologically diagnosed acute pulmonary GVHD with spontaneous remission.

摘要

一位 51 岁女性，患有成人 T 细胞白血病/淋巴瘤，为进行异基因造血干细胞移植而住院。移植后第 29 天，她开始在活动时出现缺氧。胸部计算机断层扫描显示小叶中心性颗粒状阴影，肺功能检查显示与移植前相比，阻塞性通气功能障碍显著。经支气管肺冷冻活检的组织病理学分析显示急性移植物抗宿主病（GVHD）。本文报告了一例罕见的经组织病理学诊断的急性肺 GVHD 伴自发性缓解的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/891db863af5f/1349-7235-60-2269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/0c37c2efaa06/1349-7235-60-2269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/3a1c6078eb42/1349-7235-60-2269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/b957d50052d3/1349-7235-60-2269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/891db863af5f/1349-7235-60-2269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/0c37c2efaa06/1349-7235-60-2269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/3a1c6078eb42/1349-7235-60-2269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/b957d50052d3/1349-7235-60-2269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533a/8355406/891db863af5f/1349-7235-60-2269-g004.jpg

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