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伴有僵硬和肌阵挛的进行性脑脊髓炎患者的腰大肌血肿。

Iliopsoas Hematomas in a Patient with Progressive Encephalomyelitis with Rigidity and Myoclonus.

机构信息

Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.

出版信息

Intern Med. 2021 Aug 1;60(15):2475-2477. doi: 10.2169/internalmedicine.6604-20. Epub 2021 Feb 15.

DOI:10.2169/internalmedicine.6604-20
PMID:33583898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8381190/
Abstract

Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare and severe syndrome characterized by rigidity of the limb and truncal muscles, brainstem signs, myoclonus, and hyperekplexia. Iliopsoas hematoma is a serious complication of bleeding disorders that occurs most commonly in patients with hemophilia and also in association with anti-coagulant drug treatment. We herein present a case of PERM complicated with bilateral iliopsoas hematomas. His neurological symptoms improved after immunotherapy, and thereafter the iliopsoas hematomas disappeared. Neurologists should consider iliopsoas hematomas as a serious potential complication of PERM.

摘要

进行性脑脊髓炎伴僵硬和肌阵挛（PERM）是一种罕见且严重的综合征，其特征为肢体和躯干肌肉僵硬、脑干征、肌阵挛和强肌反射亢进。髂腰肌血肿是出血性疾病的严重并发症，最常见于血友病患者，也与抗凝药物治疗有关。本文报告了一例 PERM 合并双侧髂腰肌血肿的病例。他的神经症状在免疫治疗后得到改善，此后髂腰肌血肿消失。神经病学家应将髂腰肌血肿视为 PERM 的一种严重潜在并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9aa/8381190/a841b3f5ec99/1349-7235-60-2475-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9aa/8381190/0ff68d09d202/1349-7235-60-2475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9aa/8381190/a841b3f5ec99/1349-7235-60-2475-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9aa/8381190/0ff68d09d202/1349-7235-60-2475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9aa/8381190/a841b3f5ec99/1349-7235-60-2475-g002.jpg

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本文引用的文献

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Intramuscular Hematoma on the Psoas Muscle.腰大肌内血肿
Korean J Neurotrauma. 2019 Oct 15;15(2):234-238. doi: 10.13004/kjnt.2019.15.e29. eCollection 2019 Oct.
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Glycine receptor autoantibodies disrupt inhibitory neurotransmission.甘氨酸受体自身抗体破坏抑制性神经递质传递。
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以面瘫为首发症状的甘氨酸受体抗体阳性伴僵硬和肌阵挛的进行性脑脊髓炎：一例报告
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Spontaneous soft tissue hematomas.自发性软组织血肿。
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BMJ Case Rep. 2015 Feb 26;2015:bcr2014207517. doi: 10.1136/bcr-2014-207517.
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Glycine receptor antibody mediated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM): a rare but treatable neurological syndrome.甘氨酸受体抗体介导的僵人综合征伴进行性脑脊髓炎（PERM）：一种罕见但可治疗的神经综合征。
Pract Neurol. 2014 Apr;14(2):123-7. doi: 10.1136/practneurol-2013-000511. Epub 2013 Apr 5.
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Tetanus: pathophysiology, treatment, and the possibility of using botulinum toxin against tetanus-induced rigidity and spasms.破伤风：病理生理学、治疗以及使用肉毒毒素对抗破伤风引起的僵硬和痉挛的可能性。
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