Department of Stem Cell and Infectious Diseases, KaviKrishna Laboratory, Guwahati Biotech Park, Indian Institute of Technology, Guwahati, India.
KaviKrishna Telemedicine Care, Sualkuchi, India.
Front Immunol. 2021 Jan 21;11:594572. doi: 10.3389/fimmu.2020.594572. eCollection 2020.
(), the causative organism of pulmonary tuberculosis (PTB) now infects more than half of the world population. The efficient transmission strategy of the pathogen includes first remaining dormant inside the infected host, next undergoing reactivation to cause post-primary tuberculosis of the lungs (PPTBL) and then transmit aerosol to the community. In this review, we are exploring recent findings on the role of bone marrow (BM) stem cell niche in dormancy and reactivation that may underlie the mechanisms of PPTBL development. We suggest that pathogen's interaction with the stem cell niche may be relevant in potential inflammation induced PPTBL reactivation, which need significant research attention for the future development of novel preventive and therapeutic strategies for PPTBL, especially in a post COVID-19 pandemic world. Finally, we put forward potential animal models to study the stem cell basis of dormancy and reactivation.
结核分枝杆菌（Mycobacterium tuberculosis），俗称结核杆菌，是肺结核（pulmonary tuberculosis，PTB）的病原体，现已感染了全球一半以上的人口。该病原体的高效传播策略包括：首先在受感染宿主内保持休眠状态，然后再激活以引起原发性肺结核（primary tuberculosis of the lungs，PTBL），最后将飞沫传播到社区。在这篇综述中，我们探讨了骨髓（bone marrow，BM）干细胞龛在休眠和激活中的作用的最新发现，这些发现可能是原发性肺结核发病机制的基础。我们认为，病原体与干细胞龛的相互作用可能与潜在的炎症诱导的原发性肺结核复发有关，这需要未来对新型预防和治疗策略进行深入研究，特别是在 COVID-19 大流行之后。最后，我们提出了潜在的动物模型，以研究休眠和激活的干细胞基础。
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