Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China.
Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, China.
Front Immunol. 2021 Jul 22;12:695278. doi: 10.3389/fimmu.2021.695278. eCollection 2021.
Tuberculosis (TB) is one of the communicable diseases caused by (Mtb) infection, affecting nearly one-third of the world's population. However, because the pathogenesis of TB is still not fully understood and the development of anti-TB drug is slow, TB remains a global public health problem. In recent years, with the gradual discovery and confirmation of the immunomodulatory properties of mesenchymal stem cells (MSCs), more and more studies, including our team's research, have shown that MSCs seem to be closely related to the growth status of Mtb and the occurrence and development of TB, which is expected to bring new hope for the clinical treatment of TB. This article reviews the relationship between MSCs and the occurrence and development of TB and the potential application of MSCs in the treatment of TB.
结核病（TB）是由（Mtb）感染引起的传染病之一，影响了近三分之一的世界人口。然而，由于结核病的发病机制尚不完全清楚，抗结核药物的开发缓慢，结核病仍然是一个全球性的公共卫生问题。近年来，随着间充质干细胞（MSCs）免疫调节特性的逐步发现和确认，包括我们团队的研究在内的越来越多的研究表明，MSCs 似乎与 Mtb 的生长状态以及 TB 的发生和发展密切相关，这有望为结核病的临床治疗带来新的希望。本文综述了 MSCs 与 TB 的发生和发展的关系以及 MSCs 在治疗 TB 中的潜在应用。
