Cooperrider Jessica, Momin Arbaz, Baker Kenneth B, Machado Andre G
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195.
Department of Neurosciences, Cleveland Clinic, Cleveland, OH, 44195.
Curr Phys Med Rehabil Rep. 2020 Jun;8(2):57-63. doi: 10.1007/s40141-019-00253-4. Epub 2020 Feb 20.
This paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation.
We have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating dentate nucleus stimulation for improvement of hemiparesis due to stroke is currently underway, and results thus far are encouraging.
Activation of the rodent cerebellar dentate nucleus promotes functional motor recovery following stroke. Although results of a Phase I clinical trial are pending, substantial preclinical evidence indicates that deep brain stimulation of the dentate nucleus is a promising therapeutic modality.
本文综述了目前小脑深部脑刺激用于中风康复的临床前和临床证据。
我们已在啮齿动物模型中证明了小脑刺激对中风康复的有效性，其他研究小组也重现了这一结果。损伤周围皮层的突触形成、神经发生和功能替代可能是该疗法有效性的机制基础。一项研究齿状核刺激改善中风后偏瘫的I期临床试验正在进行中，目前的结果令人鼓舞。
啮齿动物小脑齿状核的激活可促进中风后功能运动恢复。虽然I期临床试验的结果尚未得出，但大量临床前证据表明，齿状核深部脑刺激是一种有前景的治疗方式。
