抗菌药物耐药性的变化与医疗相关性感染的结局。
Changes in antimicrobial resistance and outcomes of health care-associated infections.
机构信息
Department of Infectious Diseases and Clinical Microbiology, Umraniye Research and Training Hospital University of Health Science, Elmalıkent, Adem Yavuz Cd., 34764, Ümraniye/İstanbul, Turkey.
Department of Infectious Diseases and Clinical Microbiology, School of Medicine, University of Kocaeli, Kocaeli, Turkey.
出版信息
Eur J Clin Microbiol Infect Dis. 2021 Aug;40(8):1737-1742. doi: 10.1007/s10096-020-04140-y. Epub 2021 Feb 14.
To describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%.
为了描述医疗保健相关性感染（HAI）的流行病学变化、耐药性和病死率预测因素，我们在 2015 年至 2018 年间在 24 家医院进行了一项全国性研究。2015 年的 30 天病死率为 22%，2018 年增至 25%。在血流感染中，念珠菌和肠球菌的耐药率呈显著上升趋势。肺炎患者的 30 天病死率最高（32%）。在肺炎中，2018 年铜绿假单胞菌感染增加。黏菌素耐药性增加，并与铜绿假单胞菌感染的 30 天病死率显著相关。金黄色葡萄球菌中甲氧西林耐药性从 31%增加到 41%。
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