Sergentanis Ioannis, Vibert Vincent, Costanza Alessandra, De Néris Mélanie, Besson Marie, Kosel Markus, Bondolfi Guido, Ambrosetti Julia
Unité d'accueil et d'urgences psychiatriques, Service des urgences, Département de médecine aiguë, HUG, 1211 Genève 14.
Département de psychiatrie, Faculté de médecine, UNIGE, 1211 Genève 4.
Rev Med Suisse. 2021 Feb 10;17(725):303-306.
Ketamine and its S-enantiomer, esketamine, have shown to be promising molecules for use in psychiatry. Widely investigated for the treatment of drug-resistant depression, they could be used in emergency conditions, due to their rapid onset of action, in two main conditions : 1) psychomotor agitation, and 2) acute suicidal ideation and behavior (suicidal crisis). In particular, intranasal administration offers a non-invasive, safe and very easy to administer option. An effect begins a few hours to a day after intake and lasts for about a week. These molecules present an innovative option for the future and their specific use in psychiatric emergencies.
氯胺酮及其S-对映体艾氯胺酮已被证明是用于精神病学领域的有前景的分子。它们被广泛研究用于治疗难治性抑郁症，由于起效迅速，可用于两种主要紧急情况：1）精神运动性激越，以及2）急性自杀意念和行为（自杀危机）。特别是，鼻内给药提供了一种非侵入性、安全且非常易于给药的选择。服用后数小时至一天开始起效，持续约一周。这些分子为未来以及它们在精神科急诊中的特定应用提供了一种创新选择。
