Olsson H, Möller T R, Ranstam J, Borg A, Fernö M
Department of Oncology, University Hospital, Lund, Sweden.
Anticancer Res. 1988 Jan-Feb;8(1):29-32.
The survival of 193 premenopausal breast cancer patients was investigated in relation to their history of early use of oral contraceptives. The women were born in 1939 or later and diagnosed in the southern health care region of Sweden. Women, who had started their oral contraceptive use (OC-use) before 20 years of age had a significantly lower survival rate as compared with those who had never used OC and late users (p = 0.02 and = 0.04 respectively, generalized Wilcoxon test). For women who started OC-use between 20 to 25 years of age, a tendency for a shorter survival was seen in comparison with women who had never used OC (p = 0.18). For all patients simultaneously, the relative risk adjusted for age at diagnosis increased for earlier OC-start. When only stages II and III were considered in a stratified multivariate model, a significantly elevated risk was seen for early users of OC irrespective of age or of adjuvant treatment given. The estrogen and progesterone receptor concentrations of the primary tumor were significantly lower among early users (p = 0.001 and p = 0.05 respectively).
对193名绝经前乳腺癌患者的生存情况进行了调查，研究其早期使用口服避孕药的历史。这些女性出生于1939年或之后，在瑞典南部医疗保健地区被诊断出患有乳腺癌。与从未使用过口服避孕药的女性和晚期使用者相比，在20岁之前开始使用口服避孕药（OC-使用）的女性生存率显著较低（分别为p = 0.02和p = 0.04，广义Wilcoxon检验）。对于在20至25岁之间开始使用OC的女性，与从未使用过OC的女性相比，有生存时间较短的趋势（p = 0.18）。对于所有患者同时而言，根据诊断时年龄调整后的相对风险随着OC开始使用时间的提前而增加。当在分层多变量模型中仅考虑II期和III期患者时，无论年龄或给予的辅助治疗如何，OC早期使用者的风险均显著升高。早期使用者原发性肿瘤的雌激素和孕激素受体浓度显著较低（分别为p = 0.001和p = 0.05）。
