雌二醇、糖尿病、大脑衰老之间的相互作用与认知障碍风险。
Interactions between estradiol, diabetes, and brain aging and the risk for cognitive impairment.
机构信息
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Department of Biostatistics & Data Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
出版信息
Climacteric. 2021 Aug;24(4):359-365. doi: 10.1080/13697137.2021.1877652. Epub 2021 Feb 15.
Abstract
The Women's Health Initiative Memory Study reported that older women using conjugated equine estrogens hormone therapy (HT) with or without medroxyprogesterone acetate were at increased risk for probable dementia and smaller brain volumes. These adverse effects were greatest among women who had type 2 diabetes mellitus (T2DM) at baseline or who developed the disease during follow-up. This review summarizes existing literature from randomized trials, observational studies, and preclinical studies to provide a fundamental understanding of the effects of the interaction between T2DM and HT on cognitive and metabolic health changes in brain aging.
摘要
妇女健康倡议记忆研究报告称，使用结合型马雌激素激素治疗（HT）的老年女性，无论是否同时使用醋酸甲羟孕酮，其患可能的痴呆症和脑体积缩小的风险增加。这些不利影响在基线时患有 2 型糖尿病（T2DM）或在随访期间发生该疾病的女性中最大。这篇综述总结了来自随机试验、观察性研究和临床前研究的现有文献，以提供对 T2DM 和 HT 之间相互作用对大脑衰老的认知和代谢健康变化影响的基本理解。
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本文引用的文献
1
The 2020 Menopausal Hormone Therapy Guidelines.
J Menopausal Med. 2020 Aug;26(2):69-98. doi: 10.6118/jmm.20000.
2
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing.
Nat Rev Drug Discov. 2020 Sep;19(9):609-633. doi: 10.1038/s41573-020-0072-x. Epub 2020 Jul 24.
3
Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?
Neurobiol Aging. 2020 Aug;92:61-72. doi: 10.1016/j.neurobiolaging.2020.03.020. Epub 2020 Apr 8.
4
Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation.
Mol Metab. 2020 Apr;34:1-15. doi: 10.1016/j.molmet.2019.12.010. Epub 2019 Dec 23.
5
The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
Menopause. 2019 Sep;26(9):1071-1084. doi: 10.1097/GME.0000000000001326.
6
Menopausal hormone therapy and cognition.
BMJ. 2019 Mar 6;364:l877. doi: 10.1136/bmj.l877.
7
Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study.
PLoS One. 2018 Dec 12;13(12):e0207885. doi: 10.1371/journal.pone.0207885. eCollection 2018.
8
Neuroendocrine aging precedes perimenopause and is regulated by DNA methylation.
Neurobiol Aging. 2019 Feb;74:213-224. doi: 10.1016/j.neurobiolaging.2018.09.029. Epub 2018 Oct 5.
9
The Timing Hypothesis: Hormone Therapy for Treating Symptomatic Women During Menopause and Its Relationship to Cardiovascular Disease.
J Womens Health (Larchmt). 2019 May;28(5):705-711. doi: 10.1089/jwh.2018.7201. Epub 2018 Nov 28.
10
ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice.
Exp Neurol. 2019 Jan;311:33-43. doi: 10.1016/j.expneurol.2018.09.002. Epub 2018 Sep 7.
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