Tc-CN7DG: A Highly Expected SPECT Imaging Agent of Cancer with Satisfactory Tumor Uptake and Tumor-to-Nontarget Ratios.

A novel glucose derivative (CN7DG) possessing an isonitrile as a coordinating group was synthesized, and Tc-CN7DG, which was expected to be a powerful tumor imaging agent for SPECT, was prepared in a kit by the reaction of CN7DG with SnCl·2HO and TcO. Tc-CN7DG exhibited good stability and was transported via glucose transporters. Biodistribution results in mice bearing A549 tumor models showed that Tc-CN7DG had a higher uptake at the tumor sites and better tumor/blood and tumor/muscle ratios than did [F]FDG and Tc-CN5DG. SPECT/CT imaging studies showed obvious accumulation in tumor sites, suggesting that Tc-CN7DG is a promising candidate for tumor imaging. Because Tc and Re stand for a "theranostic pair", Re-CN7DG is expected to be prepared as a promising agent for tumor therapy.