Wu Shanxuan, Huang Zijun, Jiang Xiaolin, Yan Fachao, Li Yuehui, Du Chen-Xia
College of Chemistry, Zhengzhou University, Zhengzhou, 450001, P.R. China.
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.
ChemSusChem. 2021 Apr 9;14(7):1763-1766. doi: 10.1002/cssc.202100117. Epub 2021 Feb 24.
An efficient method has been developed for the reductive amination of CO by using readily available and recyclable oxofluorovanadates as catalysts. Various amines are transformed into the desired N-formylated products in moderate to excellent yields at room temperature in the presence of phenylsilane. Mechanistic studies based on in situ infrared spectroscopy suggest a reaction pathway initiated through F-Si interactions. The activated phenylsilane allows for CO insertion to produce phenylsilyl formate, which undergoes attack by the amine to generate the target product.
已经开发出一种高效方法，使用易于获得且可循环使用的氧氟钒酸盐作为催化剂，对一氧化碳进行还原胺化反应。在室温下，在苯基硅烷存在的情况下，各种胺被转化为所需的N-甲酰化产物，产率适中至优异。基于原位红外光谱的机理研究表明，反应途径是通过氟-硅相互作用引发的。活化的苯基硅烷使一氧化碳插入生成苯基甲硅烷基甲酸酯，该酯受到胺的攻击生成目标产物。
