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眼外肌肌炎,一种可能的药物反应:组织病理学和免疫病理学分析。

Myositis of an Extraocular Muscle, a Possible Drug Reaction: Histopathologic and Immunopathologic Analysis.

机构信息

Department of Ophthalmology.

Department of Pathology, New York University Langone Medical Center, New York, New York.

出版信息

Ophthalmic Plast Reconstr Surg. 2021;37(4):e141-e143. doi: 10.1097/IOP.0000000000001923.

DOI:10.1097/IOP.0000000000001923
PMID:33587420
Abstract

A 58-year-old man presented with left-sided orbital inflammation, including chemosis and a lateral rectus abduction defect. Initially presumed to represent cellulitis, the condition responded poorly to oral and intravenous antibiotics. CT showed the epicenter of an infiltrate to involve the lateral rectus. The patient improved dramatically when oral prednisone was added. Lateral rectus biopsy displayed intramuscular polyclonal lymphoid infiltrates, rich with eosinophils. Complete resolution of the inflammatory process was confirmed by a follow-up CT. The presumptive diagnosis was idiopathic orbital myositis, an uncommon condition of unknown etiology. However, the patient had taken rosuvastatin, which has been rarely associated with diplopia and ophthalmoplegia, raising the question of whether this case was truly idiopathic.

摘要

一位 58 岁男性因左眼窝炎症就诊,包括水肿和外直肌外展障碍。最初被认为是蜂窝织炎,该病症对口服和静脉注射抗生素反应不佳。CT 显示浸润的中心位于外直肌。当口服泼尼松龙加入治疗后,患者情况显著改善。外直肌活检显示肌内多克隆淋巴样浸润,富含嗜酸性粒细胞。通过后续 CT 证实炎症过程完全消退。初步诊断为特发性眼眶肌炎,这是一种病因不明的罕见疾病。然而,该患者曾服用过瑞舒伐他汀,该药物很少与复视和眼肌麻痹相关,这引发了一个问题,即该病例是否真的是特发性的。

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