Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, PR China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Osteoarthritis Cartilage. 2021 Apr;29(4):527-535. doi: 10.1016/j.joca.2020.12.023. Epub 2021 Feb 12.
To examine the cross-sectional and longitudinal associations of dietary patterns with knee symptoms and structures in patients with knee osteoarthritis (OA).
Participants with symptomatic knee OA were recruited from a randomised, placebo-controlled trial conducted in Tasmania (N = 259) and Victoria (N = 133). Diet was assessed by the Anti-Cancer Council of Victoria food frequency questionnaire. Factor analysis was used to identify dietary patterns. Knee symptoms were assessed using Western Ontario and McMaster Universities Arthritis Index (WOMAC) and structures using MRI. Multivariable linear regressions were used to examine associations.
Three dietary patterns ("high-fat", "healthy" and "mixed") were identified in whole sample. Participants with higher "healthy pattern" score had lower total WOMAC, pain, function and stiffness scores at baseline but the associations were not significant over 24 months. Three ("western", "vegetable and meat" and "mediterranean") and two ("processed" and "vegetable") patterns were identified in Tasmania and Victoria, respectively. Cross-sectionally, only "mediterranean pattern" and "vegetable pattern" scores were significantly and negatively associated with total WOMAC or function scores. Longitudinally, participants with higher "western pattern" had worsening function (β: 0.35, 95%CI: 0.03, 0.67) and total WOMAC (β: 0.40, 95%CI: 0.07, 0.72) scores; furthermore, "vegetable pattern" was associated with decreased WOMAC stiffness score (β: -0.47, 95%CI: -0.93, -0.02). In contrast, dietary patterns were largely not associated with structural changes.
Some healthy dietary patterns were associated with reduced joint symptoms but dietary patterns were not associated with joint structure in this sample with knee OA. Further studies are required to confirm these findings.
探讨饮食模式与膝骨关节炎（OA）患者膝关节症状和结构的横断面和纵向关联。
从在塔斯马尼亚（N=259）和维多利亚（N=133）进行的一项随机、安慰剂对照试验中招募了有症状的膝骨关节炎患者。通过澳大利亚维多利亚癌症委员会食物频率问卷评估饮食。使用因子分析来识别饮食模式。使用 Western Ontario 和 McMaster 大学关节炎指数（WOMAC）评估膝关节症状，使用 MRI 评估结构。使用多变量线性回归来检验相关性。
在全样本中确定了三种饮食模式（“高脂肪”、“健康”和“混合”）。“健康模式”得分较高的参与者在基线时的总 WOMAC、疼痛、功能和僵硬评分较低，但在 24 个月内这些关联并不显著。在塔斯马尼亚和维多利亚分别确定了三种（“西式”、“蔬菜和肉类”和“地中海”）和两种（“加工”和“蔬菜”）模式。横断面研究仅发现“地中海模式”和“蔬菜模式”得分与总 WOMAC 或功能评分显著负相关。纵向研究发现，“西式模式”得分较高的参与者功能恶化（β：0.35，95%CI：0.03，0.67）和总 WOMAC（β：0.40，95%CI：0.07，0.72）评分增加；此外，“蔬菜模式”与 WOMAC 僵硬评分降低相关（β：-0.47，95%CI：-0.93，-0.02）。相比之下，饮食模式与结构变化基本无关。
在这个膝骨关节炎样本中，一些健康的饮食模式与关节症状减轻有关，但与关节结构无关。需要进一步的研究来证实这些发现。
