Faculty of Education, University of Western Ontario, London, Canada.
Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada; Imaging Division, Lawson Health Research Institute, London, Canada; First Episode Mood and Anxiety Program (FEMAP), London Health Sciences Centre, London, Canada.
Neuroimage Clin. 2021;30:102575. doi: 10.1016/j.nicl.2021.102575. Epub 2021 Jan 26.
In people with mental health issues, approximately 20% have co-occurring substance use, often involving cannabis. Although emotion regulation can be affected both by major depressive disorder (MDD) and by cannabis use, the relationship among all three factors is unknown. In this study, we used fMRI to evaluate the effect that cannabis use and MDD have on brain activation during an emotion regulation task. Differences were assessed in 74 emerging adults aged 16-23 with and without MDD who either used or did not use cannabis. Severity of depressive symptoms, emotion regulation style, and age of cannabis use onset were also measured. Both MDD and cannabis use interacted with the emotion regulation task in the left temporal lobe, however the location of the interaction differed for each factor. Specifically, MDD showed an interaction with emotion regulation in the middle temporal gyrus, whereas cannabis use showed an interaction in the superior temporal gyrus. Emotion regulation style predicted activity in the right superior frontal gyrus, however, this did not interact with MDD or cannabis use. Severity of depressive symptoms interacted with the emotion regulation task in the left middle temporal gyrus. The results highlight the influence of cannabis use and MDD on emotion regulation processing, suggesting that both may have a broader impact on the brain than previously thought.
在有心理健康问题的人群中，大约有 20%的人同时存在物质使用问题，通常涉及大麻。尽管情绪调节可能受到重度抑郁症（MDD）和大麻使用的双重影响，但这三个因素之间的关系尚不清楚。在这项研究中，我们使用 fMRI 评估了大麻使用和 MDD 对情绪调节任务中大脑激活的影响。研究评估了 74 名年龄在 16-23 岁的青少年，他们有或没有 MDD，并且有或没有使用大麻。还评估了抑郁症状的严重程度、情绪调节方式和大麻使用的起始年龄。MDD 和大麻使用均与情绪调节任务在左侧颞叶相互作用，但每个因素的相互作用位置不同。具体而言，MDD 在中颞叶与情绪调节相互作用，而大麻使用在颞上回与情绪调节相互作用。情绪调节方式预测了右侧额上回的活动，但与 MDD 或大麻使用没有相互作用。抑郁症状的严重程度与左侧中颞叶的情绪调节任务相互作用。研究结果强调了大麻使用和 MDD 对情绪调节处理的影响，表明两者可能比以前认为的对大脑有更广泛的影响。
