静脉注射硝苯地平及其溶媒与生理盐水相比的急性变力作用：一项关于正常受试者收缩期时间间期的双盲研究。
Acute inotropic effects of intravenous nifedipine and its vehicle compared with saline: a double-blind study of systolic time intervals in normal subjects.
作者信息
Walley T J, Heagerty A M, Woods K L, Bing R F, Pohl J E, Barnett D B
机构信息
Department of Pharmacology and Therapeutics, University of Leicester.
出版信息
Br J Clin Pharmacol. 1988 Feb;25(2):187-93. doi: 10.1111/j.1365-2125.1988.tb03290.x.
Abstract
- The inotropic effects of intravenous nifedipine and its vehicle were studied noninvasively in a double-blind placebo controlled crossover fashion using systolic time intervals in 12 normal subjects. 2. Nifedipine caused vasodilation, a fall in systolic and diastolic blood pressure, and increased heart rate. The vehicle alone caused vasodilation and decreased systolic blood pressure, without a change in heart rate. 3. Nifedipine increased left ventricular ejection time (LVET) and decreased pre-ejection period (PEP) and the ratio PEP/LVET, whereas the vehicle alone had the opposite effect. Neither treatment affected the total duration of electromechanical systole. 4. These results suggest that the vehicle has a negative inotropic effect, which is overcome by the indirect positive inotropic effect of nifedipine when they are administered together systemically.
摘要
- 采用双盲安慰剂对照交叉试验方法，对12名正常受试者静脉注射硝苯地平及其溶媒，通过收缩期时间间期进行无创性研究，观察其变力作用。2. 硝苯地平引起血管舒张、收缩压和舒张压下降以及心率加快。单独使用溶媒引起血管舒张和收缩压下降，但心率无变化。3. 硝苯地平增加左心室射血时间（LVET），缩短射血前期（PEP）以及PEP/LVET比值，而单独使用溶媒则产生相反的作用。两种处理均不影响机电收缩的总时长。4. 这些结果提示，溶媒具有负性变力作用，当二者全身联合给药时，硝苯地平的间接正性变力作用可克服溶媒的这种负性变力作用。
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