Graduate Program in Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul, Rio Grande do Sul, Brazil.
Department of Health Sciences, Graduate Program in Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul, Rio Grande do Sul, Brazil.
Am J Hum Biol. 2022 Jan;34(1):e23575. doi: 10.1002/ajhb.23575. Epub 2021 Feb 15.
The goal of this study was to analyze whether the relationship between the rs9939609 polymorphism of the fat mass and obesity-associated gene (FTO) with nutritional status is moderated by the ponderal index (PI) at birth in children and adolescents.
A cross-sectional study evaluated 382 schoolchildren aged 6-17 years. Anthropometric variables such as waist circumference (WC), body mass index (BMI) and body fat percentage (BF%) were used to assess nutritional status. Weight and height at birth were used for the PI calculation, which was divided into tertiles (lower, middle and upper). To compare the continuous variables between genotypes of the rs9939609 polymorphism, a recessive model (TT/AT vs. AA) and covariance analysis (ANCOVA) were used.
The AA genotype of the rs9939609 polymorphism was associated with higher WC in schoolchildren born with lower PI (β = 4.40; p = .048). However, for BF%, the genotype association was found in the upper PI tertile (β = 7.35; p = .040).
The relationship between WC and BF% with rs9939609 polymorphism (FTO) seems to be moderated by PI at birth. This is an important insight, since the data for intrauterine growth, genetic factors and the presence of obesity in children and adolescents are still contradictory.
本研究旨在分析脂肪量和肥胖相关基因（FTO）rs9939609 多态性与儿童和青少年出生时体脂指数（PI）之间的关系是否受营养状况的影响。
本横断面研究共评估了 382 名 6-17 岁的学龄儿童。使用腰围（WC）、体重指数（BMI）和体脂百分比（BF%）等人体测量变量来评估营养状况。出生时的体重和身高用于计算 PI，PI 分为三分位数（低、中、高）。为了比较 rs9939609 多态性的连续变量在基因型之间的差异，采用了隐性模型（TT/AT 与 AA）和协方差分析（ANCOVA）。
rs9939609 多态性的 AA 基因型与出生时 PI 较低的学龄儿童 WC 较高有关（β=4.40；p=0.048）。然而，对于 BF%，基因型关联在 PI 较高的三分位数中发现（β=7.35；p=0.040）。
WC 和 BF%与 rs9939609 多态性（FTO）之间的关系似乎受出生时 PI 的调节。这是一个重要的见解，因为关于宫内生长、遗传因素和儿童青少年肥胖的存在的数据仍然存在争议。
