Postgraduate Program of Physical Education of Federal, University of Pelotas, Pelotas, Brazil.
Nutr Cancer. 2022;74(1):149-157. doi: 10.1080/01635581.2021.1880607. Epub 2021 Feb 16.
Physical inactivity is one of the greatest public health challenges in the 21st century. More than five million deaths a year are caused by lack of physical activity (PA) around the world. Despite its relevance to public health, about one-third of the world's adults do not meet current PA recommendations for health benefits. Thus, the aim of the present study was to investigate the association between lifetime PA and risk of breast cancer. A case-control study was conducted between November 2016 and June 2017. The cases were recruited from all cancer centers in the city of Pelotas in southern Brazil. Each case was age-matched (±5 years) with a neighborhood control enrolled based on nearby addresses of the cases. Overall, 230 cases and 231 controls were included. Lifetime leisure-time PA may decrease the odds of breast cancer (adjusted OR = 0.44; 95%CI 0.23-0.86) in the comparison between the most active with the least active quartile. PA was associated with a reduction in the odds of breast cancer. Future studies should aim at understanding the physiological pathways that could explain how an active lifestyle influences this disease, helping in the establishment of volume and intensities necessary to obtain the benefits.
身体活动不足是 21 世纪最大的公共卫生挑战之一。全球每年有超过 500 万人因缺乏身体活动而死亡。尽管身体活动与公共卫生息息相关，但全球约有三分之一的成年人未达到目前促进健康的身体活动建议量。因此，本研究旨在探讨终生身体活动与乳腺癌风险之间的关联。本病例对照研究于 2016 年 11 月至 2017 年 6 月进行。病例从巴西南部城市佩洛塔斯的所有癌症中心招募。每个病例都与年龄匹配（±5 岁）的社区对照者相匹配，这些对照者是根据病例附近的地址招募的。总共纳入了 230 例病例和 231 例对照者。在最活跃组与最不活跃组 quartile 之间的比较中，终生休闲时间身体活动可能会降低乳腺癌的发病风险（调整后的 OR = 0.44；95%CI 0.23-0.86）。身体活动与乳腺癌发病风险降低有关。未来的研究应旨在了解可能解释积极生活方式如何影响这种疾病的生理途径，从而有助于确定获得益处所需的活动量和强度。
