3541Midwestern University, Glendale, AZ, USA.
Wisconsin Veterinary Diagnostic Laboratory, Madison, WI, USA.
Vet Pathol. 2021 May;58(3):549-557. doi: 10.1177/0300985820985288. Epub 2021 Feb 16.
A cow dairy ( = 2000) in close proximity to a sheep flock had third-trimester abortions and fatalities in cows and calves over a 14-month period. Eighteen of 33 aborted fetuses (55%) had multifocal random suppurative or mononuclear meningoencephalitis with vasculitis. Seventeen of these affected fetuses had intracytoplasmic bacteria in endothelial cells, and 1 fetus with pericarditis had similar bacteria within mesothelial cells or macrophages. Immunohistochemistry for spp. or polymerase chain reaction (PCR) for or both, performed on brain or pooled tissue, were positive in all 14 tested fetuses that had meningoencephalitis and in 4/4 calves and in 3/4 tested cows that had meningoencephalitis and thrombotic vasculitis. In 1 calf and 11/11 fetuses, PCR amplicon sequences were 100% homologous to published sequences. Enzootic chlamydiosis due to was the identified cause of the late term abortions and the vasculitis and meningoencephalitis in fetuses, calves, and cows. , an uncommon bovine abortogenic agent, is a differential diagnosis in late-term aborted fetuses with meningoencephalitis, vasculitis, and polyserositis.
一个奶牛场（=2000 头）与羊群相邻，在 14 个月的时间里，奶牛和小牛出现了妊娠晚期流产和死亡。在 33 个流产胎儿中，有 18 个（55%）出现了多灶随机化脓性或单核性脑膜脑炎伴血管炎。在这些受影响的胎儿中，有 17 个胎儿的内皮细胞中有细胞质内细菌，1 个患有心包炎的胎儿在心包膜细胞或巨噬细胞内有类似的细菌。对脑或组织混合液进行的 spp. 的免疫组织化学或聚合酶链反应（PCR）检测，在所有 14 个患有脑膜脑炎的受检胎儿以及 4/4 的小牛和 3/4 的患有脑膜脑炎和血栓性血管炎的奶牛中均为阳性。在 1 头小牛和 11/11 的胎儿中，PCR 扩增子序列与已发表的 序列完全同源。由 引起的地方性衣原体病是导致晚期流产以及胎儿、小牛和奶牛血管炎和脑膜脑炎的原因。作为一种不常见的牛流产病原体，在晚期流产伴有脑膜脑炎、血管炎和多浆膜炎的胎儿中，需要进行鉴别诊断。
