体外筛选 RNA 适体得到白细胞介素 6/白细胞介素 6 受体相互作用抑制剂。
In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor.
机构信息
Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
出版信息
Biosci Biotechnol Biochem. 2021 Apr 24;85(5):1170-1174. doi: 10.1093/bbb/zbaa124.
Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6.
白细胞介素-6（IL-6）与白细胞介素-6 受体（IL-6R）亚单位结合，与 COVID-19 中的自身免疫性疾病和细胞因子风暴有关。在这项研究中，我们通过指数富集的配体系统进化，鉴定出一种新型 RNA 适体。这种 RNA 适体不仅与 IL-6R 的解离常数为 200nM，而且还抑制了 IL-6R 与 IL-6 的相互作用。
Zotero 插件