Gastrointestinal Secretion and Inflammation Research Unit, Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State, Nigeria.
Department of Physiology, School of Health and Health Technology, Federal University of Technology Akure, Akure, Nigeria.
J Basic Clin Physiol Pharmacol. 2021 Feb 15;33(3):273-283. doi: 10.1515/jbcpp-2020-0246.
Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats.
Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment.
Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA.
Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.
已有报道称，钒具有相关的治疗特性，如抗糖尿病和抗肿瘤。本研究旨在确定钒对实验性诱导的大鼠结肠炎的影响。
本研究使用了 45 只雄性 Wistar 大鼠（103±3.90g，n=15），并将它们分为三组。第 1 组（未处理的对照组）的饮用水中不添加任何物质，而第 2 组和第 3 组分别在饮用水中添加 50 和 200mg/L 的偏钒酸钠，持续 10 周。此后，通过直肠内给予 1.50mL 6%醋酸诱导结肠炎。动物在诱导前 0 天（第 0 天）、诱导后 3 天和 7 天被处死。采集血液样本用于血液学变量检测，采集远端 8cm 结肠用于宏观、组织学和生化（丙二醛-MDA、超氧化物歧化酶-SOD、过氧化氢酶-CAT、谷胱甘肽过氧化物酶-GPx 和亚硝酸盐浓度-NO）评估。
低剂量钒通过改善组织病理学和血液学变化，有利于乙酸诱导的结肠炎。大体观察显示，在第 3 天（40%和 26.20%比 2.50%）和第 7 天（80%和 66.70%比 42%），用钒处理的组（50mg/L 和 200mg/L）的愈合速度更快。钒似乎还通过上调抗氧化酶（SOD、CAT、GPx）和 NO，同时减少 MDA 的过度产生，对乙酸诱导的结肠炎发挥有益作用。
低浓度的钒作为一种必需的微量元素，可能能够促进溃疡性结肠炎的愈合过程。
