动眼神经核损伤对猫展神经核间神经元的行为学和形态学影响。

Behavioral and morphological effects of oculomotor nucleus lesion on abducens internuclear neurons in the cat.

作者信息

Delgado-Garciá J M, Escudero M, Torres B, Portillo F, Pásaro R

机构信息

Departamento de Fisiología Animal, Facultad de Biología, Universidad de Sevilla, Spain.

出版信息

Brain Res. 1988 Mar 8;443(1-2):333-7. doi: 10.1016/0006-8993(88)91629-0.

DOI:10.1016/0006-8993(88)91629-0

PMID:3359273

Abstract

The activity of identified control and injured abducens internuclear neurons was recorded during spontaneous eye movements in the alert cat. From 2 days following the electrocoagulation of the contralateral oculomotor nucleus, abducens internuclear neurons showed a quick fatigability during eye fixations not observed in controls. Discharge rate during saccades started after the beginning of the eye movement and showed a fast exponential-like decay. These abnormal responses were not further recorded from 20 days following the lesion. Morphological studies indicated that 90% of the abducens internuclear neuron population disappeared 2 months following the lesion and showed no sign of recovery one year later.

摘要

在警觉猫的自发眼球运动过程中，记录了已识别的对照侧和损伤侧展神经核间神经元的活动。在对侧动眼神经核进行电凝后2天，展神经核间神经元在眼球注视时表现出快速疲劳，而对照侧未观察到这种情况。扫视过程中的放电率在眼球运动开始后启动，并呈快速指数样衰减。损伤后20天未再记录到这些异常反应。形态学研究表明，损伤后2个月，90%的展神经核间神经元群体消失，1年后未显示恢复迹象。