β-咔啉对大鼠脑膜囊泡中γ-氨基丁酸刺激的氯离子内流的调节作用
Modulation of GABA-stimulated chloride influx by beta-carbolines in rat brain membrane vesicles.
作者信息
Malatynska E, Serra M, Ikeda M, Biggio G, Yamamura H I
机构信息
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85721.
出版信息
Brain Res. 1988 Mar 8;443(1-2):395-7. doi: 10.1016/0006-8993(88)91640-x.
PMID:3359279
Abstract
We have shown that GABA-stimulated chloride influx into membrane vesicles from the rat cerebral cortex can be enhanced or inhibited by beta-carbolines. The beta-carbolines can produce a full spectrum of responses from maximal enhancement to maximal inhibition.
摘要
我们已经表明，γ-氨基丁酸（GABA）刺激氯离子流入大鼠大脑皮层的膜囊泡，可被β-咔啉增强或抑制。β-咔啉可产生从最大增强到最大抑制的全谱反应。
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