First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355.
Yanzhou District Hospital of Traditional Chinese Medicine, Jining 272100.
Medicine (Baltimore). 2021 Feb 5;100(5):e24127. doi: 10.1097/MD.0000000000024127.
It is well known that morning blood pressure surge increases the risk of myocardial events in the first several hours post-awakening. This meta-analysis was performed to compare the antihypertensive efficacy of morning and bedtime dosing on decreasing morning blood pressure surge.
Articles in 4 databases about clinical trials of ingestion time of antihypertensive drugs were searched and performed a meta-analysis to evaluate the different effects on morning blood pressure and absolute blood pressure (BP) reduction from baseline of between bedtime administration (experimental group) and morning awaking administration (control group).
The aim of this study is to compare the antihypertensive efficacy of morning and bedtime dosing on decreasing morning blood pressure surge.
The bedtime will provide evidence support for clinicians and patients for reducing morning blood pressure surge.
This study does not require ethical approval.
众所周知，清晨血压飙升会增加觉醒后数小时内心肌事件的风险。进行这项荟萃分析是为了比较晨起和睡前给药在降低清晨血压飙升方面的降压疗效。
检索了 4 个数据库中关于降压药物服用时间的临床试验文章，并进行荟萃分析，以评估睡前给药（实验组）与晨起清醒时给药（对照组）对清晨血压和绝对血压（BP）降低的不同影响。
本研究旨在比较晨起和睡前给药在降低清晨血压飙升方面的降压疗效。
该研究结果可为临床医生和患者提供减少清晨血压飙升的证据支持。
本研究不需要伦理批准。
