Alreshidi M A, Neela V, Alsharari A S, Hamat R A, Alsalamah A A, Atshan S S, Alzoghaibi O, Shamsudin M N
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Alrajhi Colleges, Albukairiyah 5194, Saudi Arabia.
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Trop Biomed. 2017 Mar 1;34(1):1-6.
A total of 120 non-consecutive MRSA isolates were obtained from hospitalized patients at Hospital Kuala Lumpur, Malaysia. All isolates were subjected to antimicrobial susceptibility tests and genotyping based on staphylococcal cassette chromosome mec(SCCmec), Staphylococcus aureus protein A typing (spa) and multilocus sequence typing (MLST). Vast majority of MRSA isolates were resistant to more than three classes of antibiotics. Five antibiotic resistance profiles were observed among the MRSA isolates. All isolates tested were still susceptible to vancomycin. Genotyping revealed isolates are highly clonal, where all MRSA belonged to the predominant Asian clone ST239 comprising 4 spa types. Spa typing revealed four different spa types. Continuous monitoring and effective therapeutic options for Asian MRSA clone is recommended.
从马来西亚吉隆坡医院的住院患者中总共获取了120株非连续的耐甲氧西林金黄色葡萄球菌（MRSA）分离株。所有分离株都进行了抗菌药敏试验，并基于葡萄球菌盒式染色体mec（SCCmec）、金黄色葡萄球菌蛋白A分型（spa）和多位点序列分型（MLST）进行基因分型。绝大多数MRSA分离株对三类以上抗生素耐药。在MRSA分离株中观察到五种抗生素耐药谱。所有测试的分离株对万古霉素仍敏感。基因分型显示分离株具有高度克隆性，所有MRSA都属于主要的亚洲克隆ST239，包括4种spa类型。Spa分型显示有四种不同的spa类型。建议对亚洲MRSA克隆进行持续监测并采取有效的治疗方案。
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