马来西亚耐甲氧西林金黄色葡萄球菌的遗传多样性（2002 - 2020年）
Genetic Diversity among Methicillin-Resistant in Malaysia (2002-2020).
作者信息
Al-Talib Hassanain, Samsudin Syahirah, Adnan Ariza, Murugaiah Chandrika
机构信息
Department of Medical Microbiology and Parasitology, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Sungai Buloh 47000, Malaysia.
Institute for Medical and Molecular Biotechnology, Universiti Teknologi MARA (UiTM), Sungai Buloh 47000, Malaysia.
出版信息
Trop Med Infect Dis. 2022 Nov 8;7(11):360. doi: 10.3390/tropicalmed7110360.
UNLABELLED
BACKGROUND
Methicillin-resistant (MRSA) is a common organism seen in both healthcare-associated and community-associated infections worldwide and in Malaysia over the past two decades. The aim of this review is to provide a firsthand documentation of all MRSA strains prevalent in the Malaysian population from 2002 to present and briefly describe the changing patterns. 2.
METHODS
Electronic and manual intensive literature searches were conducted between 2002 and 2020, addressing issues directly related to patients and published in the English language were selected. 3.
RESULTS
The literature search retrieved a total of 2217 articles and abstracts of 27 articles. The search yielded a total of 24 articles on genotyping of MRSA in Malaysia. The study found that MRSA strains were mostly genetically related and resulted in the predominant MRSA clones that caused active infections. Thirty-six different sequence types (ST) were recorded. The highest rates of STs detected were ST239 (52.6%), ST1 (47.4%), and ST22 (42.1%). The majority of studies showed that both SCCmec types III and IV were the most common SCCm type in Malaysia, followed by SCCmec type V (57.9%). 4.
CONCLUSIONS
Both Brazilian (ST 239 IIIA) and Hungarian (ST 239-III) MRSA strains were detected in Malaysia. PFGE remains the best method for comparing MRSA strains. However, whole-genome sequencing has a promising chance to replace PFGE in the future.
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背景
耐甲氧西林金黄色葡萄球菌（MRSA）是一种在全球范围内以及过去二十年来在马来西亚的医疗相关感染和社区相关感染中常见的病原体。本综述的目的是提供2002年至今马来西亚人群中所有流行的MRSA菌株的第一手记录，并简要描述其变化模式。2.
方法
在2002年至2020年期间进行了电子和人工密集文献检索，选取直接与患者相关且以英文发表的文献。3.
结果
文献检索共获取2217篇文章和27篇文章的摘要。检索结果共得到24篇关于马来西亚MRSA基因分型的文章。研究发现，MRSA菌株大多具有遗传相关性，并导致了引起活动性感染的主要MRSA克隆。记录了36种不同的序列类型（ST）。检测到的STs发生率最高的是ST239（52.6%）、ST1（47.4%）和ST22（42.1%）。大多数研究表明，III型和IV型葡萄球菌盒式染色体 mec（SCCmec）是马来西亚最常见的SCCm类型，其次是V型SCCmec（57.9%）。4.
结论
在马来西亚检测到了巴西（ST 239 IIIA）和匈牙利（ST 239-III）的MRSA菌株。脉冲场凝胶电泳（PFGE）仍然是比较MRSA菌株的最佳方法。然而，全基因组测序在未来有有望取代PFGE。
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