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从一所公立大学健康科学专业学生中分离出的凝固酶阴性葡萄球菌(CoNS)菌株中耐甲氧西林和异质性耐药的情况。

Presence of methicillin resistance and heteroresistance among Coagulase Negative Staphylococci (CoNS) isolates obtained from Health Sciences students at a Public University.

作者信息

Pung H P, Mat Azis N, Abdul Rachman A R, Jamaluddin T Z M T, Amin Nordin S, Suhaili Z, Zakaria Z A, Mohd Desa M N

机构信息

Department of Biomedical Science, Faculty Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Department of Medical Microbiology and Parasitology, Faculty Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

出版信息

Trop Biomed. 2017 Mar 1;34(1):84-88.

Abstract

This study was carried out to investigate the Coagulase Negative Staphylococci (CoNS) nasal carriage and the presence of methicillin resistant Coagulase Negative Staphylococci (MR-CoNS) among health sciences students at Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. A total of 120 isolates of CoNS (62.5%) was isolated from 192 student volunteers. The mecA gene was detected in 15 isolates of CoNS (12.5%). Eight out of the 15 isolates of mecA positive CoNS were resistant to cefoxitin in disc diffusion test whereas the remaining seven isolates of mecA positive CoNS were susceptible to cefoxitin. Analysis of questionnaires showed no significant association between CoNS nasal carriage and the socio-demographic and risk factors except for the genders and history of cold (P < 0.050). Generally, this finding showed a relatively low level of methicillin resistance among CoNS nasal carriage from student volunteers.

摘要

本研究旨在调查马来西亚博特拉大学医学与健康科学学院健康科学专业学生中凝固酶阴性葡萄球菌(CoNS)的鼻腔携带情况以及耐甲氧西林凝固酶阴性葡萄球菌(MR-CoNS)的存在情况。从192名学生志愿者中分离出120株CoNS(62.5%)。在15株CoNS(12.5%)中检测到mecA基因。在纸片扩散试验中,15株mecA阳性CoNS中有8株对头孢西丁耐药,其余7株mecA阳性CoNS对头孢西丁敏感。问卷调查分析显示,除性别和感冒史外,CoNS鼻腔携带与社会人口统计学和风险因素之间无显著关联(P < 0.050)。总体而言,这一发现表明学生志愿者鼻腔携带的CoNS中耐甲氧西林水平相对较低。

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