Szerdahelyi P, Kása P
Central Research Laboratory, Medical University, Szeged, Hungary.
Brain Res. 1988 Mar 22;444(2):356-60. doi: 10.1016/0006-8993(88)90946-8.
Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before injection of Al gluconate and subsequently sacrificed 10 days later. The combined treatment of AF64A and Al gluconate resulted in enhanced intraneuronal accumulation of Al in the parietal cortex and hippocampus but not in the frontal cortex. Consequently, Al may not be considered to be a primary factor in the pathogenesis of Alzheimer's disease.
在单侧脑室内注射葡萄糖酸钠、葡萄糖酸铝或胆碱毒素AF64A 16天后，通过原子吸收光谱法测量大鼠额叶皮质、顶叶皮质和海马体中的铝（Al）浓度。第四组大鼠在注射葡萄糖酸铝前6天注射AF64A，随后在10天后处死。AF64A和葡萄糖酸铝联合治疗导致顶叶皮质和海马体中神经元内铝的积累增加，但额叶皮质中没有。因此，铝可能不被认为是阿尔茨海默病发病机制中的主要因素。
