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Department of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).

Cardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).

出版信息

Circ Res. 2021 Apr 16;128(8):1139-1155. doi: 10.1161/CIRCRESAHA.120.318170. Epub 2021 Feb 17.

DOI:10.1161/CIRCRESAHA.120.318170

PMID:33593074

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8049978/

Abstract

[Figure: see text].

摘要

[图：见正文]。

相似文献

1

Loss of CASK Accelerates Heart Failure Development.CASK 的缺失加速心力衰竭的发展。

Circ Res. 2021 Apr 16;128(8):1139-1155. doi: 10.1161/CIRCRESAHA.120.318170. Epub 2021 Feb 17.

2

Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.钠氢交换体1的激活足以产生诱导心肌肥大和心力衰竭的钙离子信号。

Circ Res. 2008 Oct 10;103(8):891-9. doi: 10.1161/CIRCRESAHA.108.175141. Epub 2008 Sep 5.

3

Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss.靶向肌浆网钙摄取以改善心力衰竭：成功或失败。

Circ Res. 2010 Feb 5;106(2):230-3. doi: 10.1161/CIRCRESAHA.109.210740.

4

Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.毒蕈碱刺激通过蛋白激酶G和钙/钙调蛋白依赖性蛋白激酶II调节兰尼碱受体2磷酸化，促进肌浆网钙释放。

Hypertension. 2016 Nov;68(5):1171-1178. doi: 10.1161/HYPERTENSIONAHA.116.07666. Epub 2016 Sep 19.

5

Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.钙/钙调蛋白依赖性蛋白激酶II介导的兰尼碱受体磷酸化导致脓毒症相关的心脏收缩功能障碍。

Crit Care Med. 2017 Apr;45(4):e399-e408. doi: 10.1097/CCM.0000000000002101.

6

GRK5 Controls SAP97-Dependent Cardiotoxic β Adrenergic Receptor-CaMKII Signaling in Heart Failure.GRK5调控心力衰竭中依赖SAP97的心脏毒性β肾上腺素能受体-CaMKII信号传导

Circ Res. 2020 Aug 28;127(6):796-810. doi: 10.1161/CIRCRESAHA.119.316319. Epub 2020 Jun 8.

7

Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis.心力衰竭中的糖基化嗜铬粒蛋白A：对加工过程和心肌细胞钙稳态的影响。

Circ Heart Fail. 2017 Feb;10(2). doi: 10.1161/CIRCHEARTFAILURE.116.003675.

8

Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure.心肌兰尼碱受体的CaMKIIdelta磷酸化在力-频率关系及心力衰竭中的作用

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10274-9. doi: 10.1073/pnas.1005843107. Epub 2010 May 17.

9

Remodeling of excitation-contraction coupling in the heart: inhibition of sarcoplasmic reticulum Ca(2+) leak as a novel therapeutic approach.心脏兴奋-收缩偶联的重塑：抑制肌浆网Ca(2+)泄漏作为一种新型治疗方法。

Curr Heart Fail Rep. 2007 Mar;4(1):11-7. doi: 10.1007/s11897-007-0020-7.

10

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.心肌细胞中肌浆网钙泄漏的β-肾上腺素能增强由钙/钙调蛋白依赖性蛋白激酶介导。

Circ Res. 2007 Feb 16;100(3):391-8. doi: 10.1161/01.RES.0000258172.74570.e6. Epub 2007 Jan 18.

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The Physiological and Pathological Mechanisms of LIN2, LIN7, LIN10 and Their Tripartite Complex.LIN2、LIN7、LIN10及其三方复合物的生理和病理机制

J Cell Mol Med. 2025 Aug;29(15):e70794. doi: 10.1111/jcmm.70794.

2

Cardioprotective effects of semaglutide on isolated human ventricular myocardium.司美格鲁肽对离体人心室心肌的心脏保护作用。

Eur J Heart Fail. 2025 Mar 19. doi: 10.1002/ejhf.3644.

3

Approaches to Evaluate Whole Exome Sequencing Data That Incorporate Genetic Intolerance Scores for Congenital Anomalies, Including Intronic Regions Adjacent to Exons.

本文引用的文献

1

The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.口服钙/钙调蛋白依赖性激酶II抑制剂RA608可改善心力衰竭时的收缩功能并预防心律失常。

ESC Heart Fail. 2020 Oct;7(5):2871-2883. doi: 10.1002/ehf2.12895. Epub 2020 Jul 20.

2

Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.度拉糖肽与 2 型糖尿病患者的心血管结局（REWIND）：一项双盲、随机、安慰剂对照试验。

Lancet. 2019 Jul 13;394(10193):121-130. doi: 10.1016/S0140-6736(19)31149-3. Epub 2019 Jun 9.

3

Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.

CASK 的缺失加速心力衰竭的发展。

Loss of CASK Accelerates Heart Failure Development.

机构信息

Department of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).

Cardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).

出版信息

Circ Res. 2021 Apr 16;128(8):1139-1155. doi: 10.1161/CIRCRESAHA.120.318170. Epub 2021 Feb 17.

DOI:10.1161/CIRCRESAHA.120.318170

PMID:33593074

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8049978/

Abstract

[Figure: see text].

摘要

[图：见正文]。

相似文献

1

Loss of CASK Accelerates Heart Failure Development.CASK 的缺失加速心力衰竭的发展。

Circ Res. 2021 Apr 16;128(8):1139-1155. doi: 10.1161/CIRCRESAHA.120.318170. Epub 2021 Feb 17.

2

Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.钠氢交换体1的激活足以产生诱导心肌肥大和心力衰竭的钙离子信号。

Circ Res. 2008 Oct 10;103(8):891-9. doi: 10.1161/CIRCRESAHA.108.175141. Epub 2008 Sep 5.

3

Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss.靶向肌浆网钙摄取以改善心力衰竭：成功或失败。

Circ Res. 2010 Feb 5;106(2):230-3. doi: 10.1161/CIRCRESAHA.109.210740.

4

Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.毒蕈碱刺激通过蛋白激酶G和钙/钙调蛋白依赖性蛋白激酶II调节兰尼碱受体2磷酸化，促进肌浆网钙释放。

Hypertension. 2016 Nov;68(5):1171-1178. doi: 10.1161/HYPERTENSIONAHA.116.07666. Epub 2016 Sep 19.

5

Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.钙/钙调蛋白依赖性蛋白激酶II介导的兰尼碱受体磷酸化导致脓毒症相关的心脏收缩功能障碍。

Crit Care Med. 2017 Apr;45(4):e399-e408. doi: 10.1097/CCM.0000000000002101.

6

GRK5 Controls SAP97-Dependent Cardiotoxic β Adrenergic Receptor-CaMKII Signaling in Heart Failure.GRK5调控心力衰竭中依赖SAP97的心脏毒性β肾上腺素能受体-CaMKII信号传导

Circ Res. 2020 Aug 28;127(6):796-810. doi: 10.1161/CIRCRESAHA.119.316319. Epub 2020 Jun 8.

7

Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis.心力衰竭中的糖基化嗜铬粒蛋白A：对加工过程和心肌细胞钙稳态的影响。

Circ Heart Fail. 2017 Feb;10(2). doi: 10.1161/CIRCHEARTFAILURE.116.003675.

8

Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure.心肌兰尼碱受体的CaMKIIdelta磷酸化在力-频率关系及心力衰竭中的作用

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10274-9. doi: 10.1073/pnas.1005843107. Epub 2010 May 17.

9

Remodeling of excitation-contraction coupling in the heart: inhibition of sarcoplasmic reticulum Ca(2+) leak as a novel therapeutic approach.心脏兴奋-收缩偶联的重塑：抑制肌浆网Ca(2+)泄漏作为一种新型治疗方法。

Curr Heart Fail Rep. 2007 Mar;4(1):11-7. doi: 10.1007/s11897-007-0020-7.

10

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.心肌细胞中肌浆网钙泄漏的β-肾上腺素能增强由钙/钙调蛋白依赖性蛋白激酶介导。

Circ Res. 2007 Feb 16;100(3):391-8. doi: 10.1161/01.RES.0000258172.74570.e6. Epub 2007 Jan 18.

引用本文的文献

1

The Physiological and Pathological Mechanisms of LIN2, LIN7, LIN10 and Their Tripartite Complex.LIN2、LIN7、LIN10及其三方复合物的生理和病理机制

J Cell Mol Med. 2025 Aug;29(15):e70794. doi: 10.1111/jcmm.70794.

2

Cardioprotective effects of semaglutide on isolated human ventricular myocardium.司美格鲁肽对离体人心室心肌的心脏保护作用。

Eur J Heart Fail. 2025 Mar 19. doi: 10.1002/ejhf.3644.

3

Approaches to Evaluate Whole Exome Sequencing Data That Incorporate Genetic Intolerance Scores for Congenital Anomalies, Including Intronic Regions Adjacent to Exons.

本文引用的文献

1

The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.口服钙/钙调蛋白依赖性激酶II抑制剂RA608可改善心力衰竭时的收缩功能并预防心律失常。

ESC Heart Fail. 2020 Oct;7(5):2871-2883. doi: 10.1002/ehf2.12895. Epub 2020 Jul 20.

2

Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.度拉糖肽与 2 型糖尿病患者的心血管结局（REWIND）：一项双盲、随机、安慰剂对照试验。

Lancet. 2019 Jul 13;394(10193):121-130. doi: 10.1016/S0140-6736(19)31149-3. Epub 2019 Jun 9.

3

Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.

评估全外显子组测序数据的方法，该方法纳入了先天性异常的遗传不耐受评分，包括外显子相邻的内含子区域。

Mol Genet Genomic Med. 2025 Mar;13(3):e70092. doi: 10.1002/mgg3.70092.

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The biological functions and pathological mechanisms of CASK in various diseases.CASK在各种疾病中的生物学功能和病理机制。

Heliyon. 2024 Mar 29;10(8):e28863. doi: 10.1016/j.heliyon.2024.e28863. eCollection 2024 Apr 30.

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Ion channel trafficking implications in heart failure.离子通道转运在心力衰竭中的意义。

Front Cardiovasc Med. 2024 Feb 14;11:1351496. doi: 10.3389/fcvm.2024.1351496. eCollection 2024.

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Diverse Clinical Phenotypes of -Related Disorders and Multiple Functional Domains of CASK Protein.- 相关疾病的多种临床表型和 CASK 蛋白的多个功能域。

Genes (Basel). 2023 Aug 20;14(8):1656. doi: 10.3390/genes14081656.

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Mosaicism of a Truncating Variant of Causes Congenital Heart Disease and Neurodevelopmental Disorder.一种截短变异体的嵌合现象导致先天性心脏病和神经发育障碍。

Mol Syndromol. 2023 Jan;13(6):517-521. doi: 10.1159/000524375. Epub 2022 May 5.

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An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors.SGLT2 抑制剂的心脏-肾脏保护机制概述。

Int J Mol Sci. 2022 Mar 26;23(7):3651. doi: 10.3390/ijms23073651.

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The Non-Linear Path from Gene Dysfunction to Genetic Disease: Lessons from the MICPCH Mouse Model.从基因功能障碍到遗传性疾病的非线性路径：MICPCH 小鼠模型的启示。

Cells. 2022 Mar 28;11(7):1131. doi: 10.3390/cells11071131.

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Cardiac Fibrosis Is a Risk Factor for Severe COVID-19.心脏纤维化是 COVID-19 重症的一个风险因素。

Front Immunol. 2021 Oct 22;12:740260. doi: 10.3389/fimmu.2021.740260. eCollection 2021.

恩格列净可降低分离的心室肌细胞中的 Ca/钙调蛋白依赖性激酶 II 活性。

ESC Heart Fail. 2018 Aug;5(4):642-648. doi: 10.1002/ehf2.12336.

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Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy.肌膜蛋白介导膜微管形成，并将T小管生物发生与肌肉营养不良联系起来。

J Cell Sci. 2017 Mar 1;130(5):841-852. doi: 10.1242/jcs.198861. Epub 2017 Jan 19.

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Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes.横向膜特异性 MAGUK CASK 下调心肌细胞中的 NaV1.5 通道。

Circ Res. 2016 Aug 5;119(4):544-56. doi: 10.1161/CIRCRESAHA.116.309254. Epub 2016 Jun 30.

6

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.利拉鲁肽与2型糖尿病患者的心血管结局

N Engl J Med. 2016 Jul 28;375(4):311-22. doi: 10.1056/NEJMoa1603827. Epub 2016 Jun 13.

7

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.钙调蛋白依赖性蛋白激酶 II 是一种 RIP3 底物，介导缺血和氧化应激诱导的心肌细胞坏死性凋亡。

Nat Med. 2016 Feb;22(2):175-82. doi: 10.1038/nm.4017. Epub 2016 Jan 4.

8

Oxidant stress promotes disease by activating CaMKII.氧化应激通过激活钙调蛋白激酶II促进疾病发生。

J Mol Cell Cardiol. 2015 Dec;89(Pt B):160-7. doi: 10.1016/j.yjmcc.2015.10.014. Epub 2015 Oct 22.

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S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ.S-亚硝基化诱导钙/钙调蛋白依赖性蛋白激酶II δ的自主激活和抑制。

J Biol Chem. 2015 Oct 16;290(42):25646-56. doi: 10.1074/jbc.M115.650234. Epub 2015 Aug 27.

10

Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner.增强的晚期钠电流以钙调蛋白依赖性方式诱导致心律失常的肌浆网钙泄漏。

J Mol Cell Cardiol. 2014 Nov;76:94-105. doi: 10.1016/j.yjmcc.2014.08.016. Epub 2014 Aug 27.

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Suppr 超能文献

文献检索

文件翻译

深度研究

CASK 的缺失加速心力衰竭的发展。

Loss of CASK Accelerates Heart Failure Development.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

CASK 的缺失加速心力衰竭的发展。

Loss of CASK Accelerates Heart Failure Development.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献