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miRNA 和 mRNA 表达的遗传调控和遗传率与磷利用和肠道微生物组有关。

Genetic regulation and heritability of miRNA and mRNA expression link to phosphorus utilization and gut microbiome.

机构信息

Leibniz Institute for Farm Animal Biology, Institute for Genome Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.

Institute of Animal Science, University of Hohenheim, 70599 Stuttgart, Germany.

出版信息

Open Biol. 2021 Feb;11(2):200182. doi: 10.1098/rsob.200182. Epub 2021 Feb 17.

DOI:10.1098/rsob.200182
PMID:33593158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8061690/
Abstract

Improved utilization of phytates and mineral phosphorus (P) in monogastric animals contributes significantly to preserving the finite resource of mineral P and mitigating environmental pollution. In order to identify pathways and to prioritize candidate genes related to P utilization (PU), the genomic heritability of 77 and 80 trait-dependent expressed miRNAs and mRNAs in 482 Japanese quail were estimated and eQTL (expression quantitative trait loci) were detected. In total, 104 miR-eQTL (microRNA expression quantitative traits loci) were associated with SNP markers (false discovery rate less than 10%) including 41 eQTL of eight miRNAs. Similarly, 944 mRNA-eQTL were identified at the 5% False discovery rate threshold, with 573 being cis-eQTL of 36 mRNAs. High heritabilities of miRNA and mRNA expression coincide with highly significant eQTL. Integration of phenotypic data with transcriptome and microbiome data of the same animals revealed genetic regulated mRNA and miRNA transcripts (SMAD3, CAV1, ENNPP6, ATP2B4, miR-148a-3p, miR-146b-5p, miR-16-5p, miR-194, miR-215-5p, miR-199-3p, miR-1388a-3p) and microbes () that are associated with PU. The results reveal novel insights into the role of mRNAs and miRNAs in host gut tissue functions, which are involved in PU and other related traits, in terms of the genetic regulation and inheritance of their expression and in association with microbiota components.

摘要

提高单胃动物中植酸和矿物磷 (P) 的利用率，对于保护矿物 P 的有限资源和减轻环境污染具有重要意义。为了确定与 P 利用 (PU) 相关的途径和优先考虑的候选基因，对 482 只日本鹌鹑中 77 个和 80 个与性状相关的表达 miRNA 和 mRNA 的基因组遗传力进行了估计，并检测了 eQTL（表达数量性状基因座）。总共发现了 104 个与 SNP 标记相关的 miR-eQTL（microRNA 表达数量性状基因座）（错误发现率小于 10%），其中包括 8 个 miRNA 的 41 个 eQTL。同样，在 5%的假发现率阈值下，鉴定出了 944 个 mRNA-eQTL，其中 573 个是 36 个 mRNA 的顺式 eQTL。miRNA 和 mRNA 表达的高遗传力与高度显著的 eQTL 相吻合。将表型数据与同一动物的转录组和微生物组数据进行整合，揭示了受遗传调控的 mRNA 和 miRNA 转录物（SMAD3、CAV1、ENNPP6、ATP2B4、miR-148a-3p、miR-146b-5p、miR-16-5p、miR-194、miR-215-5p、miR-199-3p、miR-1388a-3p）和微生物（）与 PU 相关。研究结果揭示了 mRNA 和 miRNA 在宿主肠道组织功能中的作用的新见解，这些功能涉及到它们的表达的遗传调控和遗传以及与微生物群落成分的关联，与 PU 和其他相关性状有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5e/8061690/41f02ba101c3/rsob200182f09.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5e/8061690/41f02ba101c3/rsob200182f09.jpg

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G3 (Bethesda). 2020 Jul 7;10(7):2553-2562. doi: 10.1534/g3.120.401424.
3
Effects on the Ileal Microbiota of Phosphorus and Calcium Utilization, Bird Performance, and Gender in Japanese Quail.
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Animals (Basel). 2020 May 19;10(5):885. doi: 10.3390/ani10050885.
4
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5
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6
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7
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8
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