• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于 SEER 人群分析的乳腺浸润性筛状癌的临床特征和总生存预后列线图

Clinical characteristics and overall survival prognostic nomogram for invasive cribriform carcinoma of breast: a SEER population-based analysis.

机构信息

Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.

Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.

出版信息

BMC Cancer. 2021 Feb 16;21(1):168. doi: 10.1186/s12885-021-07895-5.

DOI:10.1186/s12885-021-07895-5
PMID:33593316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7887783/
Abstract

BACKGROUND

The prognositc factors in patient with invasive cribriform carcinoma (ICC) of breast is still remain controversal. The study aims to establish a nomogram to predict the survival outcomes in patients with ICC based on the Surveillance, Epidemiology and End Results (SEER) database.

METHODS

We retrieved SEER database for clinical data about patients including ICC and infiltrating ductal carcinoma (IDC) from 2004 to 2015. Kaplan-Meier survival was used to compare the difference survival outcomes between ICC and IDC. ICC patients were randomly allocated to training cohort and validation cohort. A nomogram was built to predict individual patient's 3-year and 5-year survival status for ICC. The established TMN model and the newly established nomogram was further evaluated by the concordance index (C-index) and the decision curve analysis (DCA).

RESULTS

Comparing the baseline clinical data between IDC and ICC, a significant of smaller tumor mass, less infiltrated lymph nodes, lower metastases rate, better tumor differentiation degree, higher proportion of estrogen receptor (ER) and progesterone receptor (PR) positive and lower rate of chemotherapy and radiotherapy was found in ICC. Age at diagnosis, marriage status, tumor location, T stage, M stage, ER status, surgery were independent significant prognostic factors for the overall survival (OS). A significantly higher C-index was found in nomogram compared with established TNM model in validation cohort.

CONCLUSIONS

The prognosis of ICC patients is better than that of IDC patients. The nomogram is recommended for future patient with ICC to survival analysis.

摘要

背景

浸润性筛状癌（ICC）患者的预后因素仍存在争议。本研究旨在基于监测、流行病学和最终结果（SEER）数据库建立预测 ICC 患者生存结局的列线图。

方法

我们从 2004 年至 2015 年的 SEER 数据库中检索了 ICC 和浸润性导管癌（IDC）患者的临床数据。Kaplan-Meier 生存分析用于比较 ICC 和 IDC 之间生存结局的差异。ICC 患者被随机分配到训练队列和验证队列。建立列线图以预测 ICC 患者 3 年和 5 年的生存状况。进一步通过一致性指数（C 指数）和决策曲线分析（DCA）评估新建立的 TMN 模型和列线图。

结果

比较 IDC 和 ICC 的基线临床数据，ICC 中肿瘤体积较小、浸润淋巴结较少、转移率较低、肿瘤分化程度较好、雌激素受体（ER）和孕激素受体（PR）阳性比例较高、化疗和放疗比例较低。诊断时年龄、婚姻状况、肿瘤位置、T 分期、M 分期、ER 状态、手术是总生存期（OS）的独立预后因素。验证队列中，列线图的 C 指数明显高于已建立的 TNM 模型。

结论

ICC 患者的预后优于 IDC 患者。建议未来的 ICC 患者使用列线图进行生存分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/733415727bbd/12885_2021_7895_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/43635b1d275b/12885_2021_7895_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/40577d86e0ae/12885_2021_7895_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/4726715992ed/12885_2021_7895_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/c98b5061eb4b/12885_2021_7895_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/c0850f58279c/12885_2021_7895_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/733415727bbd/12885_2021_7895_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/43635b1d275b/12885_2021_7895_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/40577d86e0ae/12885_2021_7895_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/4726715992ed/12885_2021_7895_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/c98b5061eb4b/12885_2021_7895_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/c0850f58279c/12885_2021_7895_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d443/7887783/733415727bbd/12885_2021_7895_Fig6_HTML.jpg

相似文献

1
Clinical characteristics and overall survival prognostic nomogram for invasive cribriform carcinoma of breast: a SEER population-based analysis.基于 SEER 人群分析的乳腺浸润性筛状癌的临床特征和总生存预后列线图
BMC Cancer. 2021 Feb 16;21(1):168. doi: 10.1186/s12885-021-07895-5.
2
Clinicopathological Characteristics and Survival Outcomes of Invasive Cribriform Carcinoma of Breast: A SEER Population-Based Study.乳腺浸润性筛状癌的临床病理特征及生存结局：一项基于监测、流行病学和最终结果（SEER）数据库的人群研究
Medicine (Baltimore). 2015 Aug;94(31):e1309. doi: 10.1097/MD.0000000000001309.
3
Clinical characteristics and overall survival prognostic nomogram for metaplastic breast cancer.化生性乳腺癌的临床特征及总生存预后列线图
Front Oncol. 2023 Mar 2;13:1030124. doi: 10.3389/fonc.2023.1030124. eCollection 2023.
4
Invasive micropapillary carcinoma of the breast has a better long-term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case-control analysis.尽管乳腺浸润性微乳头状癌临床表现具有侵袭性，但与乳腺浸润性导管癌相比，其长期生存率更高：基于大型人群数据库和病例对照分析的比较
Cancer Med. 2017 Dec;6(12):2775-2786. doi: 10.1002/cam4.1227. Epub 2017 Oct 26.
5
Risk factors, prognostic factors, and nomograms for bone metastasis in patients with newly diagnosed infiltrating duct carcinoma of the breast: a population-based study.基于人群的研究：初诊浸润性导管乳腺癌患者骨转移的风险因素、预后因素和列线图。
BMC Cancer. 2020 Nov 25;20(1):1145. doi: 10.1186/s12885-020-07635-1.
6
A convenient clinical nomogram for predicting the cancer-specific survival of individual patients with small-intestine adenocarcinoma.用于预测个体小肠腺癌患者癌症特异性生存的便捷临床列线图。
BMC Cancer. 2020 Jun 1;20(1):505. doi: 10.1186/s12885-020-06971-6.
7
A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma.对11400例纯黏液性乳腺癌病例进行长期随访的回顾性研究。
Breast Cancer Res Treat. 2008 Oct;111(3):541-7. doi: 10.1007/s10549-007-9809-z. Epub 2007 Nov 18.
8
Clinical Nomogram for Predicting Survival Outcomes in Early Mucinous Breast Cancer.预测早期黏液性乳腺癌生存结局的临床列线图
PLoS One. 2016 Oct 19;11(10):e0164921. doi: 10.1371/journal.pone.0164921. eCollection 2016.
9
The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast.根据乳腺癌的分子亚型，评估浸润性导管癌、小叶癌和混合性导管及小叶癌的预后。
Breast Cancer. 2021 Jan;28(1):187-195. doi: 10.1007/s12282-020-01146-4. Epub 2020 Aug 18.
10
Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy.预测接受手术和化疗的胃腺癌患者生存情况的列线图。
BMC Cancer. 2020 Jan 6;20(1):10. doi: 10.1186/s12885-019-6495-2.

引用本文的文献

1
Development and validation of a nomogram for predicting overall and cancer-specific survival in elderly patients (≥ 65 years) with epithelial ovarian cancer.用于预测老年（≥65岁）上皮性卵巢癌患者总生存期和癌症特异性生存期的列线图的开发与验证。
Eur J Med Res. 2025 Sep 1;30(1):831. doi: 10.1186/s40001-025-03114-0.
2
Prognostic value of FDG PET/CT in special types of breast cancer with non-favorable histology.18F-氟脱氧葡萄糖正电子发射断层显像/X线计算机体层成像（FDG PET/CT）在组织学类型不佳的特殊类型乳腺癌中的预后价值
Discov Oncol. 2025 Jul 31;16(1):1450. doi: 10.1007/s12672-025-03278-5.
3
Invasive cribriform carcinoma of the breast presenting as an erythematous papule on the nipple: A case report.

本文引用的文献

1
Invasive cribriform carcinoma of the breast: a clinicopathological analysis of 12 cases with review of literature.乳腺浸润性筛状癌：12例临床病理分析并文献复习
Int J Clin Exp Pathol. 2017 Sep 1;10(9):9917-9924. eCollection 2017.
2
An Updated Review of Cribriform Carcinomas with Emphasis on Histopathological Diagnosis and Prognostic Significance.筛状癌的最新综述：重点关注组织病理学诊断及预后意义
Oncol Rev. 2017 Mar 10;11(1):317. doi: 10.4081/oncol.2017.317. eCollection 2017 Mar 3.
3
A Nomogram to Predict Brain Metastases of Resected Non-Small Cell Lung Cancer Patients.
以乳头处红斑丘疹为表现的乳腺浸润性筛状癌：一例报告
Clin Case Rep. 2024 Jun 4;12(6):e9055. doi: 10.1002/ccr3.9055. eCollection 2024 Jun.
4
A nomogram for predicting the risk of male breast cancer for overall survival.用于预测男性乳腺癌总体生存风险的列线图。
Front Oncol. 2023 Aug 4;13:1068187. doi: 10.3389/fonc.2023.1068187. eCollection 2023.
5
A rare case of breast invasive cribriform carcinoma.一例罕见的乳腺浸润性筛状癌。
Radiol Case Rep. 2023 Jan 6;18(3):1049-1052. doi: 10.1016/j.radcr.2022.12.022. eCollection 2023 Mar.
6
Prognostic relevance of mixed histological subtypes in invasive breast carcinoma: a retrospective analysis.浸润性乳腺癌中混合组织学亚型的预后相关性：一项回顾性分析。
J Cancer Res Clin Oncol. 2023 Jul;149(8):4967-4978. doi: 10.1007/s00432-022-04443-x. Epub 2022 Oct 31.
预测可切除非小细胞肺癌患者脑转移的列线图。
Ann Surg Oncol. 2016 Sep;23(9):3033-9. doi: 10.1245/s10434-016-5206-3. Epub 2016 Apr 18.
4
Clinicopathological Characteristics and Survival Outcomes of Invasive Cribriform Carcinoma of Breast: A SEER Population-Based Study.乳腺浸润性筛状癌的临床病理特征及生存结局：一项基于监测、流行病学和最终结果（SEER）数据库的人群研究
Medicine (Baltimore). 2015 Aug;94(31):e1309. doi: 10.1097/MD.0000000000001309.
5
Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.乳腺浸润性筛状癌：9例报告并文献复习
Oncol Lett. 2015 Apr;9(4):1753-1758. doi: 10.3892/ol.2015.2972. Epub 2015 Feb 17.
6
Invasive cribriform carcinoma of the breast: mammographic, sonographic, MRI, and 18 F-FDG PET-CT features.乳腺浸润性筛状癌：乳腺X线摄影、超声、MRI及18F-FDG PET-CT特征
Acta Radiol. 2015 Jun;56(6):644-51. doi: 10.1177/0284185114538425. Epub 2014 Jun 17.
7
Estimation of C-index for cox proportional hazards model with censored biomarker covariate subject to limits of detection.针对具有受检测限影响的删失生物标志物协变量的Cox比例风险模型的C指数估计。
J Biopharm Stat. 2015;25(3):459-73. doi: 10.1080/10543406.2014.920859.
8
A nomogram for predicting individual survival of patients with gastric cancer who underwent radical surgery with extended lymph node dissection.用于预测接受根治性手术伴扩大淋巴结清扫术的胃癌患者个体生存的列线图。
Gastric Cancer. 2014 Apr;17(2):287-93. doi: 10.1007/s10120-013-0270-x. Epub 2013 May 29.
9
Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified.中国人群中的浸润性筛状癌：与非特殊类型的低级别浸润性导管癌的比较。
Int J Clin Exp Pathol. 2013;6(3):445-57. Epub 2013 Feb 15.
10
Clinical relevance of TNM staging system according to breast cancer subtypes.TNM 分期系统在乳腺癌亚型中的临床相关性。
Ann Oncol. 2011 Jul;22(7):1554-1560. doi: 10.1093/annonc/mdq617. Epub 2011 Jan 17.