Department of ENT, Christian Medical College, Vellore, India.
Department of Biostatistics, Christian Medical College, Vellore, India.
J Laryngol Otol. 2021 Feb;135(2):147-152. doi: 10.1017/S0022215121000396. Epub 2021 Feb 17.
Chronic rhinosinusitis is associated with altered mucociliary clearance and olfaction. The study aimed to analyse the reversibility of impairment and endoscopic factors predicting changes in mucociliary clearance and olfactory parameters.
This prospective study included patients undergoing functional endoscopic sinus surgery for medically refractory chronic rhinosinusitis. Pre- and post-operative measurements of mucociliary clearance, olfactory thresholds, and identification scores were recorded.
Of the 96 patients, 65.6 per cent had polyposis and 80.2 per cent underwent primary surgery. Improvements in mucociliary clearance and olfaction scores were seen in all patients, with greater reversibility of impairment in patients with polyposis and in those who underwent revision surgery. The presence of polyps correlated significantly with changes in mucociliary clearance and olfaction.
The study highlights improvements in mucociliary clearance, olfactory thresholds and identification scores after functional endoscopic sinus surgery in chronic rhinosinusitis with or without nasal polyposis, as well as for primary and revision surgeries. Adequate post-operative care and prevention of polyps recurrence help to improve mucociliary clearance and olfaction scores.
慢性鼻-鼻窦炎与黏膜纤毛清除功能和嗅觉改变有关。本研究旨在分析黏膜纤毛清除功能和嗅觉参数损伤的可逆性，以及预测黏膜纤毛清除功能变化的内镜相关因素。
这是一项前瞻性研究，纳入了因药物难治性慢性鼻-鼻窦炎而行功能性内镜鼻窦手术的患者。记录术前和术后的黏膜纤毛清除功能、嗅觉阈值和识别评分。
96 例患者中，65.6%有息肉，80.2%行初次手术。所有患者的黏膜纤毛清除功能和嗅觉评分均有所改善，息肉患者和接受翻修手术的患者的损伤可逆性更好。息肉的存在与黏膜纤毛清除功能和嗅觉的变化显著相关。
本研究强调了在伴有或不伴有鼻息肉的慢性鼻-鼻窦炎中，行功能性内镜鼻窦手术后黏膜纤毛清除功能、嗅觉阈值和识别评分的改善，无论是初次手术还是翻修手术。充分的术后护理和预防息肉复发有助于提高黏膜纤毛清除功能和嗅觉评分。
