College of Pharmacy (KHM, SOK, SJO, JMH, KEL), Chungbuk National University, Cheongju-si, Republic of Korea.
College of Pharmacy (KHM, SOK, SJO, JMH, KEL), Chungbuk National University, Cheongju-si, Republic of Korea.
Am J Geriatr Psychiatry. 2021 Dec;29(12):1177-1185. doi: 10.1016/j.jagp.2021.01.016. Epub 2021 Jan 30.
The data showing the association between gout and dementia are inconsistent. The objective of this study was to examine whether gout is associated with the risk of dementia in the elderly.
This retrospective cohort study used population-based representative claims data from the National Health Insurance Service in Korea. We used the Elderly Cohort database which represents 10% of the elderly Koreans over the age of 60, from 2002 to 2013. We assessed the association of gout with a new diagnosis of dementia with Cox proportional hazard models and adjusted the data for potential covariates such as demographics (age, sex) and comorbidities.
We included 22,178 patients with gout and 113,590 without. In each group, 2,557 (11.53%) and 18,264 (16.08%) patients, respectively, had dementia. In multivariable analyses, gout was independently associated with a significantly lower hazard ratio of incident dementia, with an adjusted hazard ratio of 0.63 (95% CI, 0.60-0.66). A sub-group analysis conducted to find out the effects of gout medication showed that febuxostat use significantly decreased incident dementia.
Gout was independently associated with a 37% lower risk of dementia in the elderly.
痛风与痴呆之间的关联数据并不一致。本研究旨在探讨痛风是否与老年人痴呆的风险相关。
本回顾性队列研究使用了来自韩国国家健康保险服务的基于人群的代表性索赔数据。我们使用了代表 2002 年至 2013 年韩国 60 岁以上 10%老年人的老年队列数据库。我们使用 Cox 比例风险模型评估了痛风与新发痴呆的相关性，并调整了数据以考虑潜在的混杂因素，如人口统计学因素（年龄、性别）和合并症。
我们纳入了 22178 例痛风患者和 113590 例无痛风患者。在每组中，分别有 2557 例（11.53%）和 18264 例（16.08%）患者患有痴呆。在多变量分析中，痛风与新发痴呆的风险显著降低相关，调整后的风险比为 0.63（95%CI，0.60-0.66）。我们进行了亚组分析以探究痛风药物治疗的影响，结果表明，非布司他的使用显著降低了新发痴呆的风险。
痛风与老年人痴呆的风险降低 37%独立相关。
