Department of Pharmacology, Pharmacovigilance unit/Research and Development, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Department of Pharmacology, Department of Obstetrics and Gynecology, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Kathmandu Univ Med J (KUMJ). 2020 Apr-Jun;18(70):186-192.
Background Pregnancy or gestation is the time during which a single or more children grows and develops inside a woman. Antenatal care improves the pregnancy outcomes under which a group of medication i.e. iron, folic acid and calcium are supplemented. Despite the effectiveness of such supplements, poor clinical outcomes are often encountered because of poor-adherence to the regimen. Objective To determine the adherence pattern and factors affecting adherence in antenatal care patients under iron, folic acid, and calcium therapy. Method A cross-sectional study was conducted in Dhulikhel Hospital, Kathmandu University Hospital. Pregnant women attending antenatal care under iron, folic acid, and calcium therapy fulfilling the inclusion criteria were enrolled in this study. After obtaining the informed consent from the patients, structured questionnaire was used to interview the patients. Statistical analysis was performed by using SPSS 23.0. P-value < 0.05 was considered as statistically significant. Result Among 191 patients enrolled in this study majority (39.3%) of them belonged to age group 26-30 years. More than half (61.3%) of the patients were illiterate. Of the total 191, 64.40% were non-adherent to the medication. Forgetfulness was the main reason for missing the dose in majority (52.06%) of the non-adherent subjects while adverse effects (55.40%) was the most prominent cause for discontinuing the medication among non-adherent participants. Significant association was found between patients' adherence and busy work schedule, visiting doctor for follow up. Conclusion More than half of the patients had not adhered to the medication under antenatal care. Forgetfulness was the most common factor for missing the dose in nonadherent patients. Illiteracy was associated with poor adherence. Patient-provider relationship, Socio-economic factors were determined as major barrier to medication adherence.
妊娠或怀孕是指一个或多个孩子在女性体内生长和发育的时期。产前护理可以改善药物治疗的妊娠结局,例如补充铁、叶酸和钙。尽管这些补充剂有效,但由于对治疗方案的依从性差,常常会出现不良的临床结局。
确定铁、叶酸和钙治疗下产前护理患者的依从模式和影响其依从性的因素。
在加德满都大学医院的杜利凯尔医院进行了一项横断面研究。本研究纳入了正在接受铁、叶酸和钙治疗的符合纳入标准的产前护理患者。在获得患者的知情同意后,使用结构化问卷对患者进行访谈。使用 SPSS 23.0 进行统计分析。P 值<0.05 被认为具有统计学意义。
在纳入本研究的 191 名患者中,大多数(39.3%)年龄在 26-30 岁之间。超过一半(61.3%)的患者是文盲。在总共 191 名患者中,有 64.40%的患者不遵守药物治疗方案。大多数不遵守治疗方案的患者(52.06%)忘记服药是错过剂量的主要原因,而不遵守治疗方案的患者(55.40%)中最主要的停药原因是药物不良反应。患者的依从性与忙碌的工作时间表、随访就诊之间存在显著关联。
超过一半的患者在产前护理期间未遵医嘱服药。不遵守治疗方案的患者中,忘记服药是最常见的原因。文盲与较差的依从性相关。患者-提供者关系、社会经济因素被确定为药物依从性的主要障碍。