长期给予四肽胃泌素对Wistar大鼠实验性诱导肠化生的抑制作用。

Inhibitory effect of prolonged administration of tetragastrin on experimentally induced intestinal metaplasia in Wistar rats.

作者信息

Tatsuta M, Yamamura H, Baba M, Yamamoto R, Iishi H, Taniguchi H

机构信息

Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.

出版信息

Cancer. 1988 May 15;61(10):2051-6. doi: 10.1002/1097-0142(19880515)61:10<2051::aid-cncr2820611020>3.0.co;2-h.

DOI:10.1002/1097-0142(19880515)61:10<2051::aid-cncr2820611020>3.0.co;2-h

PMID:3359403

Abstract

The effect of tetragastrin on the induction of intestinal metaplasia by intragastric administration of 5% NaOH solution was investigated in Wistar rats. The prolonged administration of tetragastrin in depot form from 1 week after NaOH treatment resulted in a significant increase in basal gastric acid secretion and a significant reduction in the incidence and number of intestinal metaplasia in experiment week 35. A histologic examination showed goblet cell metaplasia and intestinal metaplasia without Paneth cells in rats treated only with olive oil. Only goblet cell metaplasia was found in rats treated with tetragastrin. These results show that the prolonged administration of tetragastrin to rats after NaOH treatment increases gastric acid secretion and suppresses the induction of intestinal metaplasia.

摘要

在Wistar大鼠中研究了四肽胃泌素对胃内给予5%氢氧化钠溶液诱导肠化生的影响。在氢氧化钠处理1周后以长效剂型长期给予四肽胃泌素，导致基础胃酸分泌显著增加，且在实验第35周时肠化生的发生率和数量显著降低。组织学检查显示，仅用橄榄油处理的大鼠出现杯状细胞化生和无潘氏细胞的肠化生。在用四肽胃泌素处理的大鼠中仅发现杯状细胞化生。这些结果表明，在氢氧化钠处理后对大鼠长期给予四肽胃泌素可增加胃酸分泌并抑制肠化生的诱导。