钠/ D -二聚体比值可预测晚期胃癌患者一线化疗的疗效及预后。

The sodium/D-dimer ratio predicts the effect of first-line chemotherapy and prognosis in patients with advanced gastric cancer.

作者信息

Zhang Liqun, Yu Guilin, Wang Zhuo, Li Fang, Zhao Guohua, Zhao Dan

机构信息

Department of Medical Oncology, Shenyang Fifth People Hospital Tiexi District, Shenyang 110020, Liaoning Province, China.

Department of General Surgery, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China.

出版信息

Am J Transl Res. 2021 Feb 15;13(2):792-802. eCollection 2021.

PMID:33594327

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7868830/

Abstract

BACKGROUND

Gastric cancer (GC) is one of the most common cancers worldwide. The survival time of patients with advanced gastric cancer (AGC) is shortened. We evaluated the role of the sodium/fibrinogen ratio (SFR) and sodium/D-dimer ratio (SDR) in predicting the first-line chemotherapy response, progression-free survival (PFS), and overall survival (OS) of patients with AGC.

METHODS

A total of 304 patients with AGC were retrospectively reviewed. SDR only was selected as a potential prognostic marker for the subsequent studies in this study. Based on the cut-off value of the SDR, the patients were divided into high-SDR and low-SDR groups and investigated for their clinicopathological features, first-line chemotherapy effects and clinical outcomes.

RESULTS

The cut-off value based on the SDR was 282.22, and the patients were divided into low-SDR (SDR ≤ 282.22) and high-SDR (SDR > 282.22) groups. The disease control rate was higher in the high-SDR group than in the low-SDR group (91.1% vs. 82.3%; = 0.036). Patients with a high SDR had a longer median PFS and OS than those with a low SDR (PFS: 206.0 vs. 134.0 days, < 0.001; OS: 435.0 vs. 295.5 days, < 0.001). The SDR was an independent prognostic indicator in the multivariable analysis of PFS ( < 0.001) and OS ( = 0.004). In subgroup analyses, among the patients with normal sodium and D-dimer levels, SDR was still a reliable prognostic indicator of PFS and OS in patients with AGC (all ≤ 0.001).

CONCLUSIONS

This study suggests that the SDR may serve as a prognostic indicator for chemotherapy outcome, PFS and OS for patients with AGC receiving first-line chemotherapy.

摘要

背景

胃癌（GC）是全球最常见的癌症之一。晚期胃癌（AGC）患者的生存时间缩短。我们评估了钠/纤维蛋白原比值（SFR）和钠/D-二聚体比值（SDR）在预测AGC患者一线化疗反应、无进展生存期（PFS）和总生存期（OS）中的作用。

方法

回顾性分析了304例AGC患者。本研究仅选择SDR作为后续研究的潜在预后标志物。根据SDR的临界值，将患者分为高SDR组和低SDR组，并对其临床病理特征、一线化疗效果和临床结局进行研究。

结果

基于SDR的临界值为282.22，患者分为低SDR组（SDR≤282.22）和高SDR组（SDR>282.22）。高SDR组的疾病控制率高于低SDR组（91.1%对82.3%；P=0.036）。高SDR患者的中位PFS和OS长于低SDR患者（PFS：206.0天对134.0天，P<0.001；OS：435.0天对295.5天，P<0.001）。在PFS（P<0.001）和OS（P=0.004）的多变量分析中，SDR是独立的预后指标。在亚组分析中，在钠和D-二聚体水平正常的患者中，SDR仍然是AGC患者PFS和OS的可靠预后指标（均P≤0.001）。