Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Psychogeriatrics. 2021 May;21(3):396-406. doi: 10.1111/psyg.12665. Epub 2021 Feb 16.
Alzheimer's disease (AD) is the commonest cause of dementia, characterized by the clinical presentation of progressive anterograde episodic memory impairment. However, atypical presentation of patients is increasingly recognized. These atypical AD include logopenic aphasia, behavioural variant AD, posterior cortical atrophy, and corticobasal syndrome. These atypical AD are more common in patients with young onset AD before the age of 65 years old. Since medical needs (including the behavioural and psychological symptoms of dementia) of atypical AD patients could be different from typical AD patients, it is important for clinicians to be aware of these atypical forms of AD. In addition, disease modifying treatment may be available in the future. This review aims at providing an update on various important subtypes of atypical AD including behavioural and psychological symptoms.
阿尔茨海默病(AD)是痴呆最常见的病因,其特征为临床呈现出进行性顺行性情节记忆障碍。然而,越来越多的患者表现出不典型症状。这些不典型 AD 包括失语法性失语症、行为变异型 AD、后部皮质萎缩和皮质基底节综合征。这些不典型 AD 在发病年龄在 65 岁之前的早发性 AD 患者中更为常见。由于不典型 AD 患者的医疗需求(包括痴呆的行为和心理症状)可能与典型 AD 患者不同,因此临床医生了解这些不典型 AD 形式非常重要。此外,未来可能会有针对疾病的治疗方法。本综述旨在提供各种重要的不典型 AD 亚型的最新信息,包括行为和心理症状。
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