Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland.
Department of Biochemistry, Medical University of Lodz, Lodz, Poland.
J Int Med Res. 2021 Feb;49(2):300060520986669. doi: 10.1177/0300060520986669.
Cryptoglandular perianal fistula is a common benign anorectal disorder that is managed mainly with surgery. A fistula is typically defined as a pathological communication between two epithelialized surfaces. More specifically, perianal fistula manifests as an abnormal tract between the anorectal canal and the perianal skin. Perianal fistulas are often characterized by significantly decreased patient quality of life. The cryptoglandular theory of perianal fistulas suggests their development from the proctodeal glands, which originate from the intersphincteric plane and perforate the internal sphincter with their ducts. Involvement of proctodeal glands in the inflammatory process could play a primary role in the formation of cryptoglandular perianal fistula. The objective of this narrative review was to investigate the current knowledge of the pathogenesis of cryptoglandular perianal fistula with the specific aims of characterizing the potential role of proinflammatory factors responsible for the development of chronic inflammation. Further studies are crucial to improve the therapeutic management of cryptoglandular perianal fistulas.
肛门腺源性肛痿是一种常见的良性肛肠疾病，主要通过手术治疗。痿通常被定义为两个上皮化表面之间的病理性通道。更具体地说，肛门痿表现为肛管和肛周皮肤之间的异常通道。肛门痿常导致患者生活质量显著下降。肛门腺源性痿的肛门腺理论表明，其起源于肛直腺，肛直腺起源于直肠环平面，通过其导管穿透内括约肌。肛直腺在炎症过程中的参与可能在肛门腺源性肛痿的形成中起主要作用。本综述的目的是研究肛门腺源性肛痿发病机制的现有知识，具体目的是描述负责慢性炎症发展的促炎因子的潜在作用。进一步的研究对于改善肛门腺源性肛痿的治疗管理至关重要。
