重症肌无力症状负担、疲劳和睡眠：它们有关联吗？
Myasthenia Symptom Burden, Fatigue, and Sleep: Are They Related?
机构信息
Department of Neurology and Neurosciences, Banner Health Clinic, Eaton, CO; and.
Department of Neurology and Neurosciences, Stanford Medical Center, Palo Alto, CA.
出版信息
J Clin Neuromuscul Dis. 2021 Mar 1;22(3):123-128. doi: 10.1097/CND.0000000000000321.
OBJECTIVE
Our aim is to explore the relationship between myasthenia gravis (MG)-related symptom burden, sleep quality, and fatigue in a diverse group of self-identified MG patients.
METHODS
Patients provided relevant myasthenia disease data and completed the MG QOL-15, Epworth sleepiness scale, Pittsburgh Sleep Quality Index, and fatigue severity score (FSS) online. MG activities of daily living scale (MG-ADL) was completed on a follow-up telephone interview.
RESULTS
One hundred ninety-six patients completed the online survey and 99 provided MG-ADL data. The mean age was 52 ± 15.34 years, 88 were acetylcholine receptor antibody positive, and 21 were muscle specific kinase positive. The mean MG-ADL was 6.81, indicating a moderate MG disease burden. Forty-seven (24%) reported high Epworth sleepiness scale scores, 152 (77%) reported high Pittsburgh Sleep Quality Index scores, and 162 (82%) reported high FSS scores. Correlation analysis correcting for body mass index and sleep apnea revealed a moderate positive correlation between MGQOL-15, MG-ADL, and FSS.
CONCLUSIONS
There is a moderate positive correlation between various MG-specific outcome measures and fatigue severity.
目的
本研究旨在探讨不同类型重症肌无力（MG）患者的 MG 相关症状负担、睡眠质量和疲劳之间的关系。
方法
患者在线提供相关的 MG 疾病数据，并完成 MG 生活质量问卷 15 项（MG-QOL-15）、爱泼沃斯嗜睡量表（Epworth sleepiness scale）、匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index）和疲劳严重程度量表（fatigue severity score，FSS）。在随后的电话访谈中，完成 MG 日常生活活动量表（MG-ADL）。
结果
196 例患者完成了在线调查，99 例提供了 MG-ADL 数据。平均年龄为 52 ± 15.34 岁，88 例乙酰胆碱受体抗体阳性，21 例肌肉特异性激酶阳性。MG-ADL 的平均得分为 6.81，表明 MG 疾病负担处于中等水平。47 例（24%）报告了高爱泼沃斯嗜睡量表评分，152 例（77%）报告了高匹兹堡睡眠质量指数评分，162 例（82%）报告了高 FSS 评分。校正体重指数和睡眠呼吸暂停后进行相关性分析，发现 MG-QOL-15、MG-ADL 和 FSS 之间存在中度正相关。
结论
MG 特异性结局指标与疲劳严重程度之间存在中度正相关。
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