通过溶剂笼蔽的电子给体-受体（EDA）络合物实现的无光催化剂、可见光介导的酰胺C(sp)-H芳基化反应
Photocatalyst-Free, Visible-Light-Mediated C(sp)-H Arylation of Amides via a Solvent-Caged EDA Complex.
作者信息
Kaur Jaspreet, Shahin Ahmed, Barham Joshua P
机构信息
Universität Regensburg, Fakultät für Chemie und Pharmazie, 93040 Regensburg, Germany.
Chemistry Department, Faculty of Science, Benha University, 13518 Benha, Egypt.
出版信息
Org Lett. 2021 Mar 19;23(6):2002-2006. doi: 10.1021/acs.orglett.1c00132. Epub 2021 Feb 17.
A photocatalyst-free and mild visible light photochemical procedure for C(sp)-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxidant. C(sp)-H arylation of the amide occurs selectively with the most electron-rich arene of the substrate. Mechanistic studies corroborate the reaction taking place in a solvent cage holding components in a close proximity.
本文描述了一种用于酰胺C(sp)-H芳基化的无光催化剂温和可见光光化学方法。该反应通过富电子芳烃底物与贫电子过硫酸盐氧化剂之间形成的电子给体-受体（EDA）络合物进行。酰胺的C(sp)-H芳基化选择性地发生在底物中电子密度最高的芳烃上。机理研究证实该反应在使各组分紧密相邻的溶剂笼中进行。
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