Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Brazil.
Expert Rev Clin Immunol. 2021 Feb;17(2):169-176. doi: 10.1080/1744666X.2021.1875820. Epub 2021 Feb 17.
: Sepsis has pro- and anti-inflammatory processes caused by infectious agents. Sepsis survivors have impaired immune response due to immunosuppression. Gene expression during the inflammatory process is guided by transcriptional access to chromatin, with post-translational changes made in histones that determine whether the loci of the inflammatory gene are active, balanced, or suppressed. For this, a review literature was performed in PubMed included 'sepsis' and 'epigenetic' and 'immunosuppression' terms until May 2020.: This review article explores the relationship between epigenetic mechanisms and the pathophysiology of sepsis. Epigenetic changes, vulnerable gene expression, and immunosuppression are related to inflammatory insults that can modify the dynamics of the central nervous system. Therefore, it is important to investigate the timing of these changes and their dynamics during the disease progression.: Epigenetic changes are associated with the main stages of sepsis, from the pathogen-host interaction to inflammation and immunosuppression. These changes are key regulators of gene expression during physiological and pathological conditions. Thus, epigenetic markers have significant prognostic and diagnostic potential in sepsis, and epigenetic changes can be explored in combination with therapeutic strategies in experimental models of the disease.
: 脓毒症有由感染因子引起的促炎和抗炎过程。脓毒症幸存者由于免疫抑制而存在免疫应答受损。炎症过程中的基因表达受染色质转录可达性指导，组蛋白发生翻译后修饰，决定炎症基因的基因座是活跃、平衡还是受抑制。为此，在 PubMed 中进行了文献复习，包括“脓毒症”和“表观遗传学”和“免疫抑制”术语，直到 2020 年 5 月。: 这篇综述文章探讨了表观遗传机制与脓毒症病理生理学之间的关系。表观遗传变化、脆弱的基因表达和免疫抑制与炎症损伤有关，这些损伤可以改变中枢神经系统的动力学。因此，研究这些变化的时间以及它们在疾病进展过程中的动态变化非常重要。: 表观遗传变化与脓毒症的主要阶段相关，从病原体-宿主相互作用到炎症和免疫抑制。这些变化是生理和病理条件下基因表达的关键调节剂。因此，在脓毒症中，表观遗传标记具有显著的预后和诊断潜力，并且可以在疾病的实验模型中结合治疗策略来探索表观遗传变化。
