Cigarette Smoke-induced Effects on Airway Basal Cells: Taking It Up a NOTCH.
作者信息
Lafkas Daniel
机构信息
Department of Immunology Discovery Genentech, Inc. South San Francisco, California.
出版信息
Am J Respir Cell Mol Biol. 2021 Apr;64(4):397-398. doi: 10.1165/rcmb.2021-0041ED.
Abstract
摘要
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Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells.香烟烟雾激活 NOTCH3 促进人呼吸道上皮细胞中的杯状细胞分化。
Am J Respir Cell Mol Biol. 2021 Apr;64(4):426-440. doi: 10.1165/rcmb.2020-0302OC.
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Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs.单细胞重建正常和特发性肺纤维化肺中基底细胞多样性。
Am J Respir Crit Care Med. 2020 Dec 1;202(11):1540-1550. doi: 10.1164/rccm.201904-0792OC.
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Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium.解析吸烟效应的细胞特异性并重建人类气道上皮中的谱系。
Nat Commun. 2020 May 19;11(1):2485. doi: 10.1038/s41467-020-16239-z.
4
Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Individuals with Asthma.阻断 Notch3 信号通路可消除哮喘患者气道上皮细胞中 MUC5AC 的产生。
Am J Respir Cell Mol Biol. 2020 Apr;62(4):513-523. doi: 10.1165/rcmb.2019-0069OC.
5
Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution.单细胞分辨率解析吸烟诱导的人支气管上皮细胞转录异质性。
Sci Adv. 2019 Dec 11;5(12):eaaw3413. doi: 10.1126/sciadv.aaw3413. eCollection 2019 Dec.
6
Excess mucus viscosity and airway dehydration impact COPD airway clearance.黏液黏稠度过高和气道脱水会影响慢性阻塞性肺疾病（COPD）患者的气道清除功能。
Eur Respir J. 2020 Jan 30;55(1). doi: 10.1183/13993003.00419-2019. Print 2020 Jan.
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Muco-Obstructive Lung Diseases.黏液阻塞性肺部疾病
N Engl J Med. 2019 May 16;380(20):1941-1953. doi: 10.1056/NEJMra1813799.
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NOTCH3 contributes to rhinovirus-induced goblet cell hyperplasia in COPD airway epithelial cells.NOTCH3 促进 COPD 气道上皮细胞中鼻病毒诱导的杯状细胞增生。
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Dev Cell. 2017 May 8;41(3):228-241. doi: 10.1016/j.devcel.2017.04.001.
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Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.治疗性抗体揭示 Notch 对成年肺部转分化的控制。
Nature. 2015 Dec 3;528(7580):127-31. doi: 10.1038/nature15715. Epub 2015 Nov 18.
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